产品概述

应用高通量、高精度的二代测序技术,覆盖610个基因的热点突变、插入缺失、基因融合、基因扩增、多态性等变异类型,为精准用药、分子分型及疗效复发检测提供全面、高价值的参考信息。包括82个靶向用药相关基因,5个MMR相关基因,18个化疗相关基因,44个免疫治疗相关基因以及其他基因。

产品特点

1.全面综合靶点检测,多基因平行检测,一次性检测肿瘤靶向治疗以及癌症发生发展相关的610个基因,精准用药指导;
2.无创便捷,灵敏准确,取材不受组织限制,ctDNA液体活检技术可精准检测低至0.1%的低频突变;
3.实时动态监测,ctDNA检测可以多个时间点、无创取样,实时动态监测药物疗效、复发及耐药等,实现肿瘤的全病程监测与管理;

适用人群

1.初次就诊,有靶向需求的肿瘤患者;2.治疗过程中用药方案出现耐药或疗效不佳,寻求更佳治疗方案患者;3.用药方案无效,经多线治疗出现进展或复发,需重新制定治疗方案患者;4.无法提供组织样本的患者可选择ctDNA液体活检方式;

检测基因

ABL1  AKT1  AKT2  ALK  APC  AR  ARAF  ATM  ABI1 ABCB1  ABCB9 ABL2  ABRAXAS1  ACE2 ACSL6 ACVR1  ACVR1B  ADGRA2  AGO2  AKT3  ALOX12B  AMER1  ANKRD11  ARFRP1  ARID1A  ARID1B  ARNT  ASXL1  ASXL2  ATRX  AURKA  AURKB  AXIN1  AXIN2  AXL  ATR  BCL2L11  B2M  BRAF  BRCA1  BRCA2  BABAM1  BAP1  BARD1  BBC3  BCL10  BCL2  BCL2L1  BCL2L2  BCL6  BCOR  BCORL1  BIRC3  BLM  BMPR1A  BRD4  BTG1  BTK  BRIP1  CALR  CBL  CCND1  CCND2  CCND3  CCNE1  CDK4  CDK6  CDKN2A  CDKN2B  CHEK2  CTNNB1  CANX CARD11  CARM1  CASC5 CASP8  CBFA2T3  CBFB  CBLB  CCN6 CCNQ CD274  CD276  CD200 CD40  CD40LG CD48 CD70  CD79A  CD79B  CD80 CD86 CDC42  CDC73  CDH1  CDK12  CDK8  CDKN1A  CDKN1B  CDKN2C  CEBPA  CENPA  CHD2  CHD4  CHEK1  CIC  COL5A1  COP1  CREBBP  CRKL  CRLF2  CSDE1  CSF1R  CSF3R  CTCF  CTLA4  CTNNA1  CTSB CTSL CTSS CUL3  CUX1  CXCR4  CYLD  CYSLTR2  CYP19A1  CYP2D6  DDR2  DAXX  DCUN1D1  DDX10 DICER1  DIS3  DMD  DNAJB1  DNMT1  DNMT3A  DNMT3B  DOT1L  DROSHA  DUSP3 DPYD  DYNC2H1  E2F3  EED  EGFL7  EGFR  EIF1AX  EIF4A2  EIF4E  ELF3  ELK4 ELOC  EMSY  EP300  EPAS1  EPCAM  EPHA3  EPHA5  EPHA7  EPHB1  ERCC3  ERCC4  ERCC5  ERBB2  ERBB3  ERBB4  ERCC1  ERCC2  ERF  ERG  ESR1  ERRFI1  ETV1  ETV6  EWSR1  EXO1  EZH1  EZH2  ERAP1 ERAP2 FAM175A  FANCA  FANCC  FANCD2  FANCE  FANCF  FANCG  FANCL  FBXW7  FGFR1  FGFR2  FGFR3  FGFR4  FLT3  FAS  FAT1  FGF10  FGF14  FGF19  FGF23  FGF3  FGF4  FGF6  FH  FLCN  FLT1  FLT4  FOXA1  FOXL2  FOXO1  FOXP1  FRS2  FUBP1  FUS  FYN  GNA11  GNAQ  GABRA6  GAS7 GATA1  GATA2  GATA3  GATA4  GATA6  GID4  GLI1  GNA13  GNAS  GPS2  GREM1  GRIN2A  GRM3  GSK3B  GEN1  GSTP1  H3f3c  H3F3B  H3F3A  HERC1 HGF  HIST1H1C  HIST1H2BD  HIST1H3A  HIST1H3B  HIST1H3C  HIST1H3D  HIST1H3E  HIST1H3F  HIST1H3G  HIST1H3H  HIST1H3I  HIST1H3J  HIST2H3C  HIST2H3D  HIST3H3  HMGB1 HMGN1 HNF1A  HOXB13  HRAS  HSD3B1  HSP90AA1  HLA-A  HLA-B  IDH1  IDH2  IGF1R  ICOSLG  ID3  IDE IFI30 IFNGR1  IGF1  IGF2  IKBKE  IKZF1  IL10  IL7R  INHA  INHBA  INPP4A  INPP4B  INPPL1  INSR  IRF2  IRF4  IRS2  IRS1  ITGAV ITGB3  JAK1  JAK2  JAK3  JUN  KDR  KIT  KRAS  KAT6A  KDM5C  KDM5A  KDM6A  KEAP1  KEL  KLF4  KLHL6  KMT2A  KMT2B  KMT2C  KMT2D  KMT5A  KNSTRN  LRP1B  LATS1  LATS2  LEF1  LGALS9 LGMN LIG1 LIG3  LMO1  LNPEP LYN  LZTR1  MAP2K1  MAP2K2  MCL1  MET  MLH1  MSH2  MSH6  MTOR  MYCN  MYD88  MAGI2  MALT1  MAP2K4  MAP3K1  MAP3K13  MAP3K14  MAPK1  MAPK3  MAPKAP1  MAX  MDC1  MED12  MEN1  MEF2B  MGA  MICA MICB MITF  MLH3  MPL  MRE11  MSH3  MSI1  MSI2  MST1R  MST1  MUTYH  MYB  MYCL  MYC  MYOD1  MDM2  MDM4  MGMT  MTHFR  NF1  NF2  NRAS  NTRK1  NBN  NCOA3  NCOR1  NEGR1  NFE2L2  NFKBIA  NKX2-1  NKX3-1  NOTCH1  NOTCH2  NOTCH4  NOTCH3  NPEPPS NPM1  NRDC NSD1  NSD2  NSD3  NTHL1  NTRK2  NTRK3  NUF2  NUP93  NUDT15 PDGFRA  PIK3CA  PIK3R1  PMS1  PMS2  POLE  PTCH1  PTEN  PAK1  PAK3  PAK5  PARP1  PAX5  PBRM1  PCNA PDCD1  PDGFRB  PDIA3 PDK1  PDPK1  PER1  PGR  PHF6  PHOX2B  PICALM PIK3C2B  PIK3C2G  PIK3C3  PIK3CD  PIK3CB  PIK3CG  PIK3R2  PIK3R3  PIM1  PLCG2  PLK2  PMAIP1  PNRC1  POLB PPARG  PPM1D  PPP2R1A  PPP4R2  PPP6C  PRDM1  PRDM14  PRDM16  PREX2  PRKAR1A  PRKD1  PRKCI  PRKDC  PRKN  PSIP1  PRSS8  PTGS2  PTP4A1  PTPN11  PTPRD  PTPRS  PTPRT  PALB2  PDCD1LG2  POLD1  QKI  RB1  RET  ROS1  RAB35  RAC1  RAC2  RAD21  RAD50  RAD51  RAD51C  RAD51B  RAD52  RAD51D  RAD54L  RAF1  RANBP2  RASA1  RARA  RBM10  RECQL  RECQL4  REL  RHEB  RHOA  RICTOR  RIT1  RNF43  RPS6KA4  RPS6KB2  RPTOR  RRAGC  RRAS  RRAS2  RTEL1  RUNX1T1  RUNX1  RXRA  RYBP  RRM1  SMARCA4  SMARCB1  SMO  SOX2  STK11  SDHA  SDHAF2  SDHB  SDHC  SDHD  SESN1  SESN2  SESN3  SETD2  SF3B1  SH2B3  SH2D1A  SHOC2  SHQ1  SLIT2  SLX4  SMAD2  SMAD4  SMAD3  SMARCD1  SMYD3  SNCAIP  SOCS1  SOS1  SOX10  SOX17  SOX9  SPOP  SPEN  SPRED1  SPTA1  SRC  SRSF2  STAG2  STAT3  STAT4  STAT5B  STAT5A  STK19  STK40  SUFU  SUZ12  SYK  SLCO1B1  TAP1  TAP2  TAPBP TAPBPL TP53  TSC1  TSC2  TAF1  TBX3  TCF3  TCF7L2  TEK  TENT5C  TERT  TET1  TET2  TGFBR1  TGFBR2  TMEM127  TMPRSS2  TNF  TNFAIP3  TNFRSF14  TNFRSF9 TNFSF14 TNFSF18 TNFSF4 TNFSF9 TOP2A  TP53BP1  TP63  TP73  TRAF2  TRAF7  TSHR  TOP1  TPP2 TYMS  TPMT  U2AF1  UPF1  UGT1A1  VHL  VEGFA  VSIR VTCN1  WT1  WWTR1  WRN  XIAP  XPO1  XRCC5 XRCC2  XPC  XRCC1  YAP1  YES1  ZBTB2  ZFHX3  ZNF217  ZNF703 

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