菜单 基因医生

该基因编码一种蛋白质,通过促进染色质凝聚和阻止转录机制的进入,介导甲状腺激素和维甲酸受体的配体非依赖性转录抑制。它是一个复合物的一部分,该复合物还包括组蛋白脱乙酰酶和类似于酵母蛋白sin3p的转录调节因子,该基因位于17号染色体上charcot-marie-tooth和smith-magnis综合征的关键区域之间。交替剪接导致多个转录变体。在17号和20号染色体上发现了该基因的假基因。[由RefSeq提供,2010年6月]
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

基因名:NCOR1
别名:N-CoR,TRAC1,N-CoR1,hN-CoR,PPP1R109
基因ID:9611
Chromosome:
(GRCh37)
17 Start: 15933408 End: 16118874 Strand: 
信号通路: 基因组不稳定 
NCOR1 基因突变与药物