| 基因名 | 疾病 | 靶向药 | 化疗药 | 基因突变 | 临床解释 |
|---|---|---|---|---|---|
| NUP93 | 0 | 0 | |||
| NUP85 | 0 | 0 | |||
| NUP210 | 0 | 0 | |||
| NUP107 | 0 | 0 | |||
| NUMA1 | 0 | 0 | |||
| NUF2 | 0 | 0 | |||
| NUDT18 | 0 | 0 | |||
| NUDT1 | 0 | 0 | |||
| NUBPL | 0 | 0 | |||
| NTRK3 | 乳腺癌,乳腺分泌癌,癌症,先天性纤维肉瘤,血液癌,髓母细胞瘤,乳头状甲状腺癌,小儿B细胞淋巴母细胞白血病,小儿B淋巴细胞白血病,小儿纤维肉瘤,唾液腺癌,实体瘤 | 克唑替尼,恩曲替尼,拉罗替尼,拉罗替尼,Selitrectinib,PLX7486, | 7 | 17 | |
| NTRK2 | 血液癌,细胞星形细胞瘤,肉瘤 | 拉罗替尼, | 3 | 3 | |
| NTRK1 | 癌症,胆管癌,结直肠癌,脂纤维瘤样神经肿瘤,肺腺癌,非小细胞肺癌,黑色素瘤,神经母细胞瘤,胰腺癌,小儿纤维肉瘤,肉瘤,实体瘤 | 拉罗替尼,克唑替尼,恩曲替尼,拉罗替尼,Lestaurtinib (CEP-701),Selitrectinib, | 12 | 28 | |
| NTM | 0 | 0 | |||
| NTHL1 | 0 | 0 | |||
| NT5E | 结直肠癌 | 西妥昔单抗, | 1 | 1 | |
| NT5C2 | 急性淋巴细胞白血病,T细胞急性淋巴细胞白血病 | Arabinosylguanine, | 巯嘌呤,硫鸟嘌呤,奈拉滨, | 3 | 8 |
| NSD3 | 0 | 0 | |||
| NSD2 | 0 | 0 | |||
| NSD1 | 0 | 0 | |||
| NRXN1 | 0 | 0 | |||
| NRP2 | 0 | 0 | |||
| NRG3 | 0 | 0 | |||
| NRG1 | 乳腺癌,癌症,胆管癌,结直肠癌,头颈部鳞状细胞癌,肺腺癌,非小细胞肺癌,粘液腺癌,卵巢癌,胰腺腺癌 | 阿法替尼,Anti-ERBB3 Agents,AV-203,西妥昔单抗,厄洛替尼,帕妥珠单抗,GSK2849330,拉帕替尼,Patritumab, | 卡铂,顺铂,吉西他滨,紫杉醇, | 5 | 13 |
| NRAS | 急性髓性白血病,癌症,结直肠癌,滤泡性甲状腺癌,头颈部鳞状细胞癌,非小细胞肺癌,恶性胸膜间皮瘤,黑色素瘤,多发性骨髓瘤,神经母细胞瘤,皮肤黑色素瘤,甲状腺癌 | Tanespimycin,Amuvatinib,Dactolisib,比美替尼、贝美替尼,西妥昔单抗,达拉非尼,厄洛替尼,依维莫司,伊匹单抗,二甲双胍,Omipalisib,帕尼单抗,瑞博西尼,RO4987655,司美替尼,替莫唑胺,曲美替尼,维莫非尼, | 多西他赛, | 18 | 103 |
| NR4A3 | 0 | 0 | |||
| NR4A2 | 0 | 0 | |||
| NR3C2 | 0 | 0 | |||
| NR3C1 | 0 | 0 | |||
| NR2F2 | 结直肠癌 | 1 | 1 | ||
| NR1I3 | 0 | 0 | |||
| NR1I2 | 0 | 0 | |||
| NQO1 | 肺癌 | 氨柔比星, | 2 | 2 | |
| NPM1 | 急性髓性白血病 | All-trans Retinoic Acid,Anti-CD123,Anti-CD33,Induction Therapy,NSC348884, | 柔红霉素,丙戊酸钠, | 2 | 34 |
| NOTCH4 | 0 | 0 | |||
| NOTCH3 | 胰腺癌,直肠癌 | 他瑞妥单抗, | 1 | 2 | |
| NOTCH2 | 0 | 0 | |||
| NOTCH1 | 急性T细胞白血病,成人T细胞白血病,慢性淋巴细胞白血病,结直肠癌,头颈鳞状细胞癌,非小细胞肺癌,套细胞淋巴瘤 | LGK974,NOTCH1 Antibody,PF-03084014, | 泼尼松, | 19 | 25 |
| NOS3 | 0 | 0 | |||
| NOS2 | 0 | 0 | |||
| NONO | 0 | 0 | |||
| NOD1 | 0 | 0 | |||
| NLRP7 | 0 | 0 | |||
| NLRP5 | 0 | 0 | |||
| NLRP3 | 0 | 0 | |||
| NLRP1 | 0 | 0 | |||
| NLRC3 | 0 | 0 | |||
| NLGN1 | 0 | 0 | |||
| NKX3-1 | 0 | 0 | |||
| NKX2-4 | 0 | 0 | |||
| NKX2-1 | 0 | 0 | |||
| NKAP | 0 | 0 | |||
| NIN | 0 | 0 | |||
| NHEJ1 | 0 | 0 | |||
| NFXL1 | 0 | 0 | |||
| NFKBIA | 0 | 0 | |||
| NFKB1 | 0 | 0 | |||
| NFE2L3 | 0 | 0 | |||
| NFE2L2 | 0 | 0 | |||
| NFE2L1 | 0 | 0 | |||
| NFATC4 | 0 | 0 | |||
| NFATC2 | 0 | 0 | |||
| NF2 | 听神经瘤,乳腺癌,腹膜间皮瘤,甲状腺癌 | 依维莫司,司美替尼,西罗莫司, | 卡铂,顺铂, | 4 | 4 |
| NF1 | 非小细胞肺癌,周围神经鞘恶性肿瘤,黑色素瘤,神经母细胞瘤,神经纤维瘤,丛状神经纤维瘤,皮肤黑色素瘤 | AZ628,比美替尼、贝美替尼,达拉非尼,JQ1 Compound,PD0325901,西罗莫司,司美替尼,曲美替尼,维莫非尼,VX-11e, | 4 | 12 | |
| NEO1 | 0 | 0 | |||
| NEK11 | 0 | 0 | |||
| NEIL3 | 0 | 0 | |||
| NEIL2 | 0 | 0 | |||
| NEIL1 | 0 | 0 | |||
| NEGR1 | 0 | 0 | |||
| NEDD9 | 肝细胞癌 | 1 | 1 | ||
| NEB | 0 | 0 | |||
| NDUFS1 | 0 | 0 | |||
| NDUFB11 | 0 | 0 | |||
| NDUFA13 | 0 | 0 | |||
| NDRG1 | 0 | 0 | |||
| NCSTN | 0 | 0 | |||
| NCOR2 | 0 | 0 | |||
| NCOR1 | 0 | 0 | |||
| NCOA6 | 0 | 0 | |||
| NCOA4 | 0 | 0 | |||
| NCOA3 | 乳腺癌 | 2 | 2 | ||
| NCOA2 | 间充质软骨肉瘤 | 1 | 6 | ||
| NCK1 | 0 | 0 | |||
| NCF4 | 0 | 0 | |||
| NCF2 | 0 | 0 | |||
| NCAM2 | 0 | 0 | |||
| NCAM1 | 0 | 0 | |||
| NBPF1 | 0 | 0 | |||
| NBN | 头颈癌 | GPI-15427, | 1 | 1 | |
| NAV3 | 0 | 0 | |||
| NAT2 | 0 | 0 | |||
| NAT1 | 0 | 0 | |||
| NAPRT | 癌症 | GNE-617, | 1 | 1 | |
| NAP1L1 | 0 | 0 | |||
| NABP2 | 0 | 0 | |||
| NAB2 | 0 | 0 | |||
| NAB1 | 0 | 0 | |||
| MYSM1 | 0 | 0 | |||
| MYOF | 0 | 0 | |||
| MYOD1 | 0 | 0 | |||
| MYO3A | 0 | 0 | |||
| MYO1B | 0 | 0 | |||
| MYO18A | 0 | 0 | |||
| MYO10 | 0 | 0 | |||
| MYH9 | 0 | 0 | |||
| MYH14 | 0 | 0 | |||
| MYH11 | 0 | 0 | |||
| MYH10 | 0 | 0 | |||
| MYD88 | 乳腺癌,慢性淋巴细胞白血病,华登斯特巨球蛋白血症 | 伊布替尼,IMG-2005-5,IRAK-1/4 Inhibitor, | 紫杉醇, | 2 | 4 |
| MYCNOS | 0 | 0 | |||
| MYCN | 髓母细胞瘤,神经母细胞瘤 | CBL0137,GSK126,JQ1,JQEZ5,比拉瑞塞,帕比司他,索尼德吉, | 三氧化二砷, | 1 | 8 |
| MYCL | 多发性骨髓瘤 | GSK1210151A,JQ1, | 1 | 1 | |
| MYC | 食管癌,小细胞肺癌,髓母细胞瘤,多发性骨髓瘤 | 伊布替尼,JQ1,奥拉帕利,Prexasertib, | 顺铂, | 2 | 4 |
| MYBL2 | 0 | 0 | |||
| MYBL1 | 0 | 0 | |||
| MYB | 急性嗜碱性白血病,小儿低级别胶质瘤（PLGG） | 2 | 2 | ||
| MYADM | 0 | 0 | |||
| MX1 | 0 | 0 | |||
| MUTYH | 0 | 0 | |||
| MUS81 | 0 | 0 | |||
| MUC6 | 0 | 0 | |||
| MUC5B | 0 | 0 | |||
| MUC16 | 0 | 0 | |||
| MUC1 | 0 | 0 | |||
| MTUS1 | 0 | 0 | |||
| MTRR | 0 | 0 | |||
| MTR | 0 | 0 | |||
| MTOR | 膀胱癌,乳腺癌,透明细胞肾细胞癌,子宫内膜腺癌,黑色素瘤,肾细胞癌,实体瘤,T细胞急性淋巴细胞白血病,甲状腺癌,尿路上皮癌 | Capivasertib,AZD8055,依维莫司,LY294002,MTOR Inhibitors,帕唑帕尼,培唑帕尼,RapaLink-1,西罗莫司, | 雷帕霉素, | 17 | 21 |
| MTMR3 | 0 | 0 | |||
| MTHFR | 胰腺癌,直肠癌,胃癌 | 氟尿嘧啶, | 1 | 3 | |
| MTHFD1 | 0 | 0 | |||
| MTF1 | 0 | 0 | |||
| MTDH | 0 | 0 | |||
| MTAP | 乳腺癌 | 氟尿嘧啶, | 1 | 1 | |
| MST1R | 0 | 0 | |||
| MST1 | 0 | 0 | |||
| MSR1 | 0 | 0 | |||
| MSN | 0 | 0 | |||
| MSI2 | 0 | 0 | |||
| MSI1 | 0 | 0 | |||
| MSH6 | 林奇综合征,尿路上皮癌 | MEDI0680,MEDI4736, | 7 | 7 | |
| MSH5 | 0 | 0 | |||
| MSH4 | 0 | 0 | |||
| MSH3 | 0 | 0 | |||
| MSH2 | 林奇综合征,尿路上皮癌 | MEDI0680,MEDI4736, | 7 | 7 | |
| MS4A3 | 0 | 0 | |||
| MS4A1 | 0 | 0 | |||
| MRPL19 | 0 | 0 | |||
| MRE11A | 子宫内膜癌,前列腺癌 | 他拉唑帕尼,奥拉帕利, | 2 | 2 | |
| MRE11 | 0 | 0 | |||
| MPO | 0 | 0 | |||
| MPL | 原发性血小板增多症,骨髓纤维化 | 2 | 2 | ||
| MOV10L1 | 0 | 0 | |||
| MOCS2 | 0 | 0 | |||
| MNX1 | 0 | 0 | |||
| MNDA | 0 | 0 | |||
| MNAT1 | 0 | 0 | |||
| MN1 | 0 | 0 | |||
| MMS19 | 0 | 0 | |||
| MMP9 | 炎性乳腺癌 | 贝伐单抗, | 1 | 1 | |
| MMP3 | 0 | 0 | |||
| MMP2 | 脑胶质瘤,炎性乳腺癌 | 贝伐单抗, | 1 | 2 | |
| MMP16 | 0 | 0 | |||
| MMP14 | 0 | 0 | |||
| MMP12 | 0 | 0 | |||
| MMP11 | 0 | 0 | |||
| MLST8 | 0 | 0 | |||
| MLLT6 | 0 | 0 | |||
| mllt4 | 0 | 0 | |||
| MLLT3 | 0 | 0 | |||
| MLLT1 | 0 | 0 | |||
| MLL3 | 0 | 0 | |||
| MLL2 | 0 | 0 | |||
| MLL | 0 | 0 | |||
| MLH3 | 0 | 0 | |||
| MLH1 | 林奇综合征,胃癌 | 奥沙利铂, | 28 | 28 | |
| MKRN3 | 0 | 0 | |||
| MKNK2 | 0 | 0 | |||
| MKNK1 | 0 | 0 | |||
| MKI67 | 乳腺癌,前列腺癌 | 1 | 2 | ||
| MITF | 黑色素瘤 | PLX4720,司美替尼, | 1 | 1 | |
| MIR218-1 | 结直肠癌,胰腺癌 | 2 | 3 | ||
| MIPOL1 | 0 | 0 | |||
| MIOS | 0 | 0 | |||
| MIEN1 | 0 | 0 | |||
| MIDN | 0 | 0 | |||
| MIB1 | 0 | 0 | |||
| MIA2 | 0 | 0 | |||
| MGMT | 变性少突胶质瘤,多形胶质母细胞瘤,恶性胶质瘤,神经内分泌瘤,少突胶质瘤 | O(6)-benzylguanine,替莫唑胺, | 卡莫司汀,洛莫司汀, | 3 | 13 |
| MGA | 0 | 0 | |||
| MET | 癌症,结直肠癌,胃腺癌,多形胶质母细胞瘤,肺腺癌,非小细胞肺癌,肺鳞状细胞癌,乳头状肾细胞癌,皮肤黑色素瘤,胃癌,葡萄膜黑色素瘤 | Anti-EGFR Monoclonal Antibody,卡博替尼,卡马替尼,西妥昔单抗,克唑替尼,厄洛替尼,Foretinib,吉非替尼,MEK Inhibitor,MET Inhibition,ErbB3 Inhibition,Naquotinib,Onartuzumab,奥希替尼,Rilotumumab,沃利替尼,司美替尼,Tepotinib,曲美替尼,维莫非尼, | 13 | 40 | |
| MERTK | 黑色素瘤 | UNC1062, | 1 | 1 | |
| MEN1 | 甲状腺损伤细胞癌 | 1 | 1 | ||
| MEIS1 | 0 | 0 | |||
| MEF2C | 0 | 0 | |||
| MEF2B | 0 | 0 | |||
| MED19 | 0 | 0 | |||
| MED12 | 0 | 0 | |||
| MECOM | 0 | 0 | |||
| MDM4 | 癌症 | 派姆单抗（帕博利珠单抗）,纳武单抗（纳武利尤单抗）,阿特朱单抗，阿替利珠单抗, | 2 | 2 | |
| MDM2 | 癌症,食道鳞状细胞癌,头颈癌,脂肪肉瘤,恶性胸膜间皮瘤 | MK-8242,派姆单抗（帕博利珠单抗）,纳武单抗（纳武利尤单抗）,伊匹单抗, | 顺铂,培美曲塞, | 4 | 6 |
| MDH2 | 0 | 0 | |||
| MDC1 | 0 | 0 | |||
| MCM3 | 0 | 0 | |||
| MCL1 | 0 | 0 | |||
| MCC | 0 | 0 | |||
| MC1R | 0 | 0 | |||
| MBD4 | 0 | 0 | |||
| MB21D2 | 0 | 0 | |||
| MAX | 0 | 0 | |||
| MARK2 | 0 | 0 | |||
| MAPKBP1 | 0 | 0 | |||
| MAPKAP1 | 0 | 0 | |||
| MAPK9 | 0 | 0 | |||
| MAPK8IP1 | 0 | 0 | |||
| MAPK8 | 0 | 0 | |||
| MAPK3 | 0 | 0 | |||
| MAPK14 | 0 | 0 | |||
| MAPK13 | 0 | 0 | |||
| MAPK1 | 头颈鳞状细胞癌,非小细胞肺癌 | 厄洛替尼,WZ4002, | 3 | 4 | |
| MAP4K5 | 0 | 0 | |||
| MAP4K3 | 0 | 0 | |||
| MAP4K1 | 0 | 0 | |||
| MAP3K4 | 0 | 0 | |||
| MAP3K14 | 0 | 0 | |||
| MAP3K13 | 0 | 0 | |||
| MAP3K1 | 0 | 0 | |||
| MAP2K7 | 肺癌 | 1 | 1 | ||
| MAP2K4 | 0 | 0 | |||
| MAP2K3 | 0 | 0 | |||
| MAP2K2 | 黑色素瘤 | 维莫非尼, | 1 | 1 | |
| MAP2K1 | 结直肠癌,朗格汉斯细胞组织细胞增多症,肺腺癌,黑色素瘤,卵巢浆膜癌 | 西妥昔单抗,达拉非尼,司美替尼,曲美替尼,维莫非尼, | 伊立替康, | 11 | 15 |
| MAN1B1 | 0 | 0 | |||
| MAML3 | 0 | 0 | |||
| MAML2 | 0 | 0 | |||
| MAML1 | 0 | 0 | |||
| MALT1 | 0 | 0 | |||
| MAGOHB | 0 | 0 | |||
| MAGOH | 0 | 0 | |||
| MAGI2 | 0 | 0 | |||
| MAGEH1 | 胆管腺癌 | 吉西他滨, | 1 | 1 | |
| MAFB | 0 | 0 | |||
| MAF | 0 | 0 | |||
| MAD1L1 | 0 | 0 | |||
| MACF1 | 0 | 0 | |||
| LZTS1 | 0 | 0 | |||
| LZTR1 | 神经鞘瘤病 | 1 | 1 | ||
| LYRM9 | 0 | 0 | |||
| LYN | 慢性髓系白血病 | 阿昔替尼,达沙替尼, | 1 | 2 | |
| LTK | 0 | 0 | |||
| LSMEM1 | 0 | 0 | |||
| LRRTM4 | 0 | 0 | |||
| LRRK2 | 0 | 0 | |||
| LRRK1 | 0 | 0 | |||
| LRRIQ3 | 0 | 0 | |||
| LRRFIP2 | 0 | 0 | |||
| LRRC7 | 0 | 0 | |||
| LRRC4C | 0 | 0 | |||
| LRRC34 | 0 | 0 | |||
| LRP6 | 0 | 0 | |||
| LRP5 | 0 | 0 | |||
| LRP4 | 0 | 0 | |||
| LRP2 | 0 | 0 | |||
| LRP1B | 多形性胶质母细胞瘤 | 多柔比星, | 2 | 2 | |
| LRP1 | 0 | 0 | |||
| LRIG3 | 0 | 0 | |||
| LRFN5 | 0 | 0 | |||
| LPP | 0 | 0 | |||
| LPL | 0 | 0 | |||
| LONRF3 | 0 | 0 | |||
| LMO1 | 0 | 0 | |||
| LIMK1 | 0 | 0 | |||
| LIG4 | 0 | 0 | |||
| LIG3 | 0 | 0 | |||
| LIFR | 0 | 0 | |||
| LHCGR | 0 | 0 | |||
| LGALS8 | 0 | 0 | |||
| LEPR | 脑膜瘤 | 1 | 1 | ||
| LEF1 | 0 | 0 | |||
| LDLR | 0 | 0 | |||
| LCP1 | 0 | 0 | |||
| LCK | 0 | 0 | |||
| LATS2 | 0 | 0 | |||
| LATS1 | 0 | 0 | |||
| LASP1 | 0 | 0 | |||
| LAMA3 | 0 | 0 | |||
| LAMA2 | 0 | 0 | |||
| LAG3 | 雌激素受体阴性乳腺癌 | 1 | 1 | ||
| L3MBTL1 | 0 | 0 | |||
| KRTAP5-5 | 0 | 0 | |||
| KRT18 | 前列腺癌 | 1 | 1 | ||
| KRAS | 急性白血病,癌症,慢性骨髓单核细胞白血病,透明细胞肉瘤,结肠癌,结直肠癌,子宫内膜癌,上皮性卵巢癌,毛细胞白血病,头颈部鳞状细胞癌,肝细胞癌,肺腺癌,肺癌,非小细胞肺癌肿瘤,肺鳞状细胞癌,淋巴瘤,黑色素瘤,多发性骨髓瘤,骨髓瘤,卵巢癌,胰腺腺癌,胰腺癌,胰腺导管癌,毛细胞星形细胞瘤,腹膜假黏液瘤,罗莎多夫曼病,皮肤黑色素瘤,皮肤鳞状细胞癌,甲状腺癌,甲状腺癌D癌,外分泌胰腺肿瘤 | 玻玛西林,玻玛西尼,Adoptive T-cell Transfer,阿法替尼,司美替尼,ARS-1620,ARS-853,阿特朱单抗，阿替利珠单抗,AZD5438,AZD8186,Refametinib,贝伐单抗,Dactolisib,比美替尼、贝美替尼,BMS-754807,西妥昔单抗,Chemotherapy,考比替尼,克唑替尼,达拉非尼,达沙替尼,Decitabine,EGFR Inhibitor,康奈非尼,厄洛替尼,Fluorouracil,G-573,GDC-0623,吉非替尼,GO-203-2C,IMO,伊沙佐米,Leucovorin,玻玛西林,玻玛西尼,MEK Inhibitor,马法兰，米尔法兰,MK-2206,纳武单抗（纳武利尤单抗）,Oxaliplatin (JAN/USAN/INN),哌柏西利,帕博西尼,帕博西林,帕尼单抗,PD0325901,哌柏西利,帕博西尼,帕博西林,派姆单抗（帕博利珠单抗）,PI103,PI3K Inhibitor,R1507,RAF265,Refametinib,瑞戈非尼,Ridaforolimus,RO4987655,SCH772984,司美替尼,Small Molecule Inhibitor,索拉非尼,舒尼替尼,西罗莫司,曲美替尼,维莫非尼, | 卡铂,顺铂,多西他赛,反法尼基硫代水杨酸,FOLFOX4方案,吉西他滨,伊立替康,奥沙利铂,紫杉醇,培美曲塞,沙利雷塞, | 35 | 397 |
| KPNB1 | 0 | 0 | |||
| KPNA4 | 0 | 0 | |||
| KNSTRN | 0 | 0 | |||
| KMT5A | 0 | 0 | |||
| KMT2E | 0 | 0 | |||
| KMT2D | 滤泡性淋巴瘤,歌舞伎综合征 | AR-42, | 2 | 2 | |
| KMT2C | 乳腺癌 | Anastrozole,依西美坦,来曲唑片, | 2 | 2 | |
| KMT2B | 0 | 0 | |||
| KMT2A | 急性髓性白血病 | 1 | 1 | ||
| KLLN | 乳腺癌,肾细胞癌 | 1 | 2 | ||
| KLK1 | 0 | 0 | |||
| KLHL6 | 0 | 0 | |||
| KLHL1 | 0 | 0 | |||
| KLF6 | 0 | 0 | |||
| KLF5 | 0 | 0 | |||
| KLF4 | 0 | 0 | |||
| KLC1 | 0 | 0 | |||
| KLB | 0 | 0 | |||
| KITLG | 0 | 0 | |||
| KIT | 肢端扁桃体黑色素瘤,急性髓系白血病,急性早幼粒细胞白血病,癌症,慢性白血病,慢性髓系白血病,结肠印戒腺癌,子宫内膜癌,胃肠道间质瘤,胃肠道系统癌,肺腺癌,肺癌,非小细胞肺癌,恶性肛门梅尔异常瘤,黑色素瘤,粘膜黑色素瘤,鼻腔未分化癌,实体瘤,全身肥大细胞增多症,胸腺癌,胸腺鳞状细胞癌 | 达沙替尼,博舒替尼,克唑替尼,达沙替尼,Gleevec,伊马替尼,Imatinib Mesylate,米哚妥林,坦度替尼,尼洛替尼,PD-180970,Pictilisib,帕纳替尼/普纳替尼/波纳替尼,瑞戈非尼,司美替尼,索拉非尼,舒尼替尼,舒尼替尼, | 87 | 329 | |
| KIR3DX1 | 0 | 0 | |||
| KIF5B | 0 | 0 | |||
| KIF2B | 0 | 0 | |||
| KIF23 | 肝细胞癌 | 1 | 1 | ||
| KIF1B | 0 | 0 | |||
| KIAA1549 | 0 | 0 | |||
| KIAA1524 | 胰腺导管腺癌 | 吉西他滨, | 2 | 2 | |
| KIAA1217 | 0 | 0 | |||
| KIAA1210 | 0 | 0 | |||
| KEL | 0 | 0 | |||
| KEAP1 | 0 | 0 | |||
| KDR | 血管肉瘤,乳腺血管肉瘤,结直肠癌 | 帕唑帕尼,培唑帕尼,瑞戈非尼,索拉非尼,舒尼替尼, | 5 | 5 | |
| KDM6A | 急性淋巴细胞白血病 | 1 | 1 | ||
| KDM5D | 0 | 0 | |||
| KDM5C | 肾细胞癌 | 依维莫司,舒尼替尼, | 1 | 1 | |
| KDM5A | 0 | 0 | |||
| KDM4C | 0 | 0 | |||
| KDM3B | 0 | 0 | |||
| KDM2B | 0 | 0 | |||
| KCNT2 | 0 | 0 | |||
| KCNQ2 | 0 | 0 | |||
| KCNJ5 | 0 | 0 | |||
| KCNJ3 | 0 | 0 | |||
| KCNJ2 | 0 | 0 | |||
| KCND2 | 0 | 0 | |||
| KCNA4 | 0 | 0 | |||
| KAT6B | 0 | 0 | |||
| KAT6A | 0 | 0 | |||
| KALRN | 0 | 0 | |||
| JUN | 结直肠癌 | 厄贝沙坦, | 1 | 1 | |
| JMJD1C | 0 | 0 | |||
| JARID2 | 0 | 0 | |||
| JAK3 | 肺腺癌,T细胞急性淋巴细胞白血病 | 阿特朱单抗，阿替利珠单抗,托法替尼, | 3 | 3 | |
| JAK2 | B细胞成人急性淋巴细胞白血病,骨髓癌,慢性髓细胞白血病,血液癌,淋巴细胞白血病,黑色素瘤,小儿B细胞急性淋巴细胞白血病,小儿B细胞淋巴细胞白血病,真性红细胞增多症,皮肤黑色素瘤 | Pegylated IFN-alpha-2a,派姆单抗（帕博利珠单抗）,芦可替尼/鲁索利替尼/鲁索替尼,Fedratinib, | 7 | 14 | |
| JAK1 | 结肠癌,肝细胞癌,非小细胞肺癌,黑色素瘤,皮肤黑色素瘤 | Enzastaurin,派姆单抗（帕博利珠单抗）,芦可替尼/鲁索利替尼/鲁索替尼, | 5 | 5 | |
| ITSN1 | 0 | 0 | |||
| ITPR2 | 0 | 0 | |||
| ITPA | 0 | 0 | |||
| ITK | 0 | 0 | |||
| ITGB3 | 0 | 0 | |||
| ITGB2 | 0 | 0 | |||
| ITGAL | 0 | 0 | |||
| IRS2 | 结直肠癌 | BMS-754807, | 1 | 1 | |
| IRS1 | 0 | 0 | |||
| IRF8 | 0 | 0 | |||
| IRF6 | 0 | 0 | |||
| IRF4 | 0 | 0 | |||
| IRF2 | 0 | 0 | |||
| IRF1 | 0 | 0 | |||
| IRAK1 | 0 | 0 | |||
| IQCJ | 0 | 0 | |||
| IPO7 | 0 | 0 | |||
| IP6K1 | 0 | 0 | |||
| INSRR | 0 | 0 | |||
| INSR | 0 | 0 | |||
| INPPL1 | 0 | 0 | |||
| INPP5D | 0 | 0 | |||
| INPP4B | 0 | 0 | |||
| INPP4A | 0 | 0 | |||
| INHBA | 0 | 0 | |||
| INHA | 0 | 0 | |||
| ING1 | 0 | 0 | |||
| IMPG1 | 0 | 0 | |||
| IL7R | 小儿B淋巴细胞白血病,T细胞急性淋巴细胞白血病 | 3 | 3 | ||
| IL6ST | 0 | 0 | |||
| IL6R | 0 | 0 | |||
| IL6 | 0 | 0 | |||
| IL2RB | 小儿B细胞急性淋巴细胞白血病 | 1 | 1 | ||
| IL21R | 0 | 0 | |||
| IL1RAPL1 | 0 | 0 | |||
| IL10 | 0 | 0 | |||
| IKZF3 | 0 | 0 | |||
| IKZF2 | 0 | 0 | |||
| IKZF1 | 急性淋巴细胞白血病,小儿B细胞淋巴细胞白血病,前体B淋巴细胞淋巴瘤/白血病 | 2 | 6 | ||
| IKBKE | 0 | 0 | |||
| IKBKB | 0 | 0 | |||
| IGSF10 | 0 | 0 | |||
| IGLL5 | 0 | 0 | |||
| IGFL3 | 0 | 0 | |||
| IGF2R | 0 | 0 | |||
| IGF2 | 卵巢癌,胰腺腺癌,前列腺癌 | 卡巴他赛,Ganitumab,Linsitinib, | 多西他赛, | 1 | 4 |
| IGF1R | 非小细胞肺癌 | 吉非替尼,IGF1R Monoclonal Antibody, | 2 | 2 | |
| IGF1 | 0 | 0 | |||
| IFNL3 | 0 | 0 | |||
| IFNGR2 | 0 | 0 | |||
| IFNGR1 | 0 | 0 | |||
| IFNG | 0 | 0 | |||
| IFNAR2 | 0 | 0 |
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