菜单 基因医生

该基因编码锌指蛋白Ikaros家族的一个成员这个蛋白家族的三个成员(Ikaros,Aiolos和Helios)是造血特异性转录因子,参与调节淋巴细胞的发育。该基因产物是一种转录因子,在调节b淋巴细胞增殖和分化中起重要作用。Ikaros和Aiolos都能参与染色质重塑。Aiolos对B淋巴细胞基因表达的调节是复杂的,因为它似乎需要依次形成Ikaros同二聚体、Ikaros/Aiolos异二聚体和Aiolos同二聚体已经描述了几种编码不同亚型的替代转录本,以及一些非蛋白编码变体。[由RefSeq提供,2012年4月]
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

基因名:IKZF3
别名:AIO,AIOLOS,ZNFN1A3
基因ID:22806
Chromosome:
(GRCh37)
17 Start: 37913968 End: 38020441 Strand: 
信号通路:  
IKZF3 基因突变与药物