菜单 基因医生

该基因编码线粒体膜呼吸链nadh脱氢酶(复合物i)的一个亚单位,其功能是将电子从nadh转移到呼吸链。该蛋白是复合物I组装和电子转移活性所必需的该蛋白结合信号转导和转录激活因子3(STAT3)转录因子,可作为肿瘤抑制因子发挥作用。从线粒体纯化的人蛋白迁移约16 kDa。已经发现来自上游启动子并且能够表达具有较长n末端的蛋白质的转录物,但是它们的生物学有效性尚未确定。[由RefSeq提供,2009年10月]
This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]

基因名:NDUFA13
别名:B16.6,CDA016,CGI-39,GRIM19,GRIM-19,MC1DN28
基因ID:51079
Chromosome:
(GRCh37)
19 Start: 19626550 End: 19639858 Strand: 
信号通路:  
NDUFA13 基因突变与药物