菜单 基因医生

该基因编码的蛋白是一种高度保守的小染色体维持蛋白(mcm),参与真核生物基因组复制的启动。MCM蛋白形成的六聚体蛋白复合物是复制前复合物(pre-RC)的关键组成部分,可能参与复制叉的形成和其它DNA复制相关蛋白的募集这种蛋白质是由MCM2-7组成的蛋白质复合物的一个亚单位它已经被证明与MCM5/CDC46直接交互这种蛋白质还与染色质相关的乙酰转移酶MCM3AP相互作用并被其乙酰化这种蛋白质的乙酰化抑制了dna复制和细胞周期进程的开始。已经发现了一些编码不同亚型的转录变体。[由RefSeq提供,2018年10月]
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]

基因名:MCM3
别名:HCC5,P1.h,RLFB,P1-MCM3
基因ID:4172
Chromosome:
(GRCh37)
6 Start: 52128812 End: 52149679 Strand: 
信号通路:  
MCM3 基因突变与药物