菜单 基因医生

这个基因编码的蛋白质是一个DNA结合,亮氨酸拉链包含转录因子,作为同二聚体或异二聚体。根据结合位点和结合伙伴,编码的蛋白质可以是转录激活物或阻遏物。这种蛋白在一些细胞过程中起调节作用,包括胚胎晶状体纤维细胞的发育,增加t细胞对凋亡的敏感性,以及软骨细胞的终末分化。该基因缺陷是幼年性粉状白内障和先天性化脓性白内障4(cca4)的病因之一。已经发现了两个编码不同亚型的转录变体。[由RefSeq提供,2010年1月]
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

基因名:MAF
别名:CCA4,AYGRP,c-MAF,CTRCT21
基因ID:4094
Chromosome:
(GRCh37)
16 Start: 79627745 End: 79634622 Strand: 
信号通路:  
MAF 基因突变与药物