菜单 基因医生

由该基因编码的蛋白质是超氧化物产生吞噬细胞NADPH氧化酶的细胞质调节成分，是一种重要的宿主防御的多组分酶系统。这种蛋白优先在髓系细胞中表达它主要与中性粒细胞胞质因子2（ncf2/p67-phox）相互作用，形成与中性粒细胞胞质因子1（ncf1/p47-phox）的复合物，并与小g蛋白rac1进一步相互作用，在细胞刺激时向细胞膜转运。然后这个复合物激活黄细胞色素b，酶系统的膜整合催化核心。该蛋白的PX结构域能与PI（3）激酶的磷脂产物结合，提示其在PI（3）激酶介导的信号转导中的作用该蛋白的磷酸化被发现对酶活性有负调节作用另外，还观察到编码不同亚型的剪接转录变体。[由RefSeq提供，2008年7月]
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]