菜单 基因医生

该基因编码的蛋白是丝氨酸/苏氨酸激酶,是一些信号转导通路的一部分,包括erk和jnk激酶途径以及nf-kappa-b途径。编码的蛋白质被自磷酸化激活,需要镁作为其他蛋白质磷酸化的辅助因子。该蛋白具有e3连接酶活性,由植物同源结构域(phd)赋予其n-末端,磷酸激酶活性由激酶结构域赋予其c-末端。[由RefSeq提供,2012年3月]
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

基因名:MAP3K1
别名:MEKK,MEKK1,SRXY6,MAPKKK1
基因ID:4214
Chromosome:
(GRCh37)
5 Start: 56110900 End: 56191979 Strand: 
信号通路: 细胞增殖  免疫相关  炎症相关  凋亡抑制 
MAP3K1 基因突变与药物