基因名 | 疾病 | 靶向药 | 化疗药 | 基因突变 | 临床解释 |
---|---|---|---|---|---|
ZZZ3 | 0 | 0 | |||
ZRSR2 | 0 | 0 | |||
ZNRF3 | 0 | 0 | |||
ZNF91 | 0 | 0 | |||
ZNF831 | 0 | 0 | |||
ZNF814 | 0 | 0 | |||
ZNF805 | 0 | 0 | |||
ZNF804B | 0 | 0 | |||
ZNF804A | 0 | 0 | |||
ZNF770 | 0 | 0 | |||
ZNF750 | 0 | 0 | |||
ZNF711 | 0 | 0 | |||
ZNF703 | 0 | 0 | |||
ZNF638 | 0 | 0 | |||
ZNF536 | 0 | 0 | |||
ZNF521 | 0 | 0 | |||
ZNF423 | 0 | 0 | |||
ZNF384 | 0 | 0 | |||
ZNF367 | 0 | 0 | |||
ZNF217 | 0 | 0 | |||
ZNF2 | 0 | 0 | |||
ZNF148 | 0 | 0 | |||
ZMYM4 | 0 | 0 | |||
ZMYM3 | 0 | 0 | |||
ZMAT3 | 0 | 0 | |||
ZIM2 | 0 | 0 | |||
ZIC4 | 0 | 0 | |||
ZIC3 | 0 | 0 | |||
ZIC1 | 0 | 0 | |||
ZFPM2 | 0 | 0 | |||
ZFP36L2 | 0 | 0 | |||
ZFP36L1 | 0 | 0 | |||
ZFHX4 | 0 | 0 | |||
ZFHX3 | 0 | 0 | |||
ZEB1 | 套细胞淋巴瘤 | 阿糖胞苷,多柔比星,吉西他滨,盐霉素, | 1 | 2 | |
ZDHHC17 | 0 | 0 | |||
ZC3H7B | 0 | 0 | |||
ZC3H11A | 0 | 0 | |||
ZBTB2 | 0 | 0 | |||
ZBTB16 | 0 | 0 | |||
ZBBX | 0 | 0 | |||
ZAN | 0 | 0 | |||
YY1AP1 | 0 | 0 | |||
YWHAZ | 0 | 0 | |||
YES1 | 0 | 0 | |||
YBX1 | 0 | 0 | |||
YAP1 | 食管癌 | 氟尿嘧啶,多西他赛,维替泊芬, | 1 | 2 | |
XRCC3 | 0 | 0 | |||
XRCC2 | 0 | 0 | |||
XRCC1 | 宫颈癌,非小细胞肺癌 | 卡铂,顺铂,多西他赛,吉西他滨,长春瑞滨, | 2 | 3 | |
XPO1 | 0 | 0 | |||
XPCC1 | 0 | 0 | |||
XPC | 0 | 0 | |||
XPA | 0 | 0 | |||
XIRP2 | 0 | 0 | |||
XIAP | 0 | 0 | |||
XBP1 | 0 | 0 | |||
WWTR1 | 上皮样血管内皮瘤 | 1 | 1 | ||
WWP2 | 0 | 0 | |||
WWP1 | 0 | 0 | |||
WWOX | 0 | 0 | |||
WWC3 | 0 | 0 | |||
WT1 | 急性髓性白血病 | 阿糖胞苷,柔红霉素, | 2 | 11 | |
WSCD2 | 0 | 0 | |||
WRN | 0 | 0 | |||
WNT7B | 0 | 0 | |||
WNT6 | 0 | 0 | |||
WNT5A | 0 | 0 | |||
WNT10B | 0 | 0 | |||
WNT10A | 0 | 0 | |||
WNT1 | 0 | 0 | |||
WNK1 | 0 | 0 | |||
WISP3 | 0 | 0 | |||
WIPF1 | 0 | 0 | |||
WHSC1L1 | 0 | 0 | |||
WHSC1 | 0 | 0 | |||
WEE2 | 0 | 0 | |||
WEE1 | 弥漫性固有桥脑胶质瘤,非小细胞肺癌 | AZD1775,PLATINUM, | 吉西他滨, | 2 | 3 |
WDTC1 | 0 | 0 | |||
WDR90 | 0 | 0 | |||
WDR5 | 0 | 0 | |||
WASF3 | 0 | 0 | |||
WAS | 0 | 0 | |||
VTCN1 | 0 | 0 | |||
VSIG10 | 0 | 0 | |||
VPS37A | 卵巢癌 | 西妥昔单抗, | 1 | 1 | |
VIM | 0 | 0 | |||
VHL | 肾上腺嗜铬细胞瘤,丘瓦什红细胞增多症,透明细胞肾细胞癌,真性红细胞增多症,肾癌,肾细胞癌,von hippel-lindau病 | 依维莫司,帕唑帕尼,培唑帕尼,芦可替尼/鲁索利替尼/鲁索替尼,舒尼替尼,西罗莫司,VEGF Inhibition, | 624 | 1527 | |
VEZF1 | 0 | 0 | |||
VEGFC | 0 | 0 | |||
VEGFB | 0 | 0 | |||
VEGFA | 结直肠癌,多形性胶质母细胞瘤,卵巢癌,胃癌 | 贝伐单抗,厄洛替尼,L-Folinic Acid, | 氟尿嘧啶,伊立替康, | 2 | 4 |
VDAC2 | 0 | 0 | |||
VAMP2 | 0 | 0 | |||
USP8 | 0 | 0 | |||
USP6 | 0 | 0 | |||
USP48 | 0 | 0 | |||
USP34 | 0 | 0 | |||
USP12 | 0 | 0 | |||
USP1 | 0 | 0 | |||
USHBP1 | 0 | 0 | |||
USH2A | 0 | 0 | |||
UROD | 0 | 0 | |||
UPF3B | 0 | 0 | |||
UPF2 | 0 | 0 | |||
UPF1 | 0 | 0 | |||
UNC5D | 0 | 0 | |||
UMPS | 0 | 0 | |||
ULK4 | 0 | 0 | |||
UGT1A9 | 0 | 0 | |||
UGT1A8 | 0 | 0 | |||
UGT1A1 | 癌症 | 贝利司他, | 2 | 2 | |
UGT1A | 结直肠癌 | Ganetespib, | 1 | 1 | |
UBR5 | 0 | 0 | |||
UBE3C | 0 | 0 | |||
UBE2E3 | 0 | 0 | |||
UBE2D2 | 0 | 0 | |||
U2AF1 | 急性髓性白血病,骨髓增生异常综合征,骨髓纤维化 | 3 | 8 | ||
TYRP1 | 0 | 0 | |||
TYRO3 | 0 | 0 | |||
TYR | 0 | 0 | |||
TYMS | 癌症,结直肠癌,胃腺癌,肺腺癌,非小细胞肺癌,前列腺癌 | 氟尿嘧啶,伊立替康,甲氨蝶呤,培美曲塞,雷替曲塞, | 5 | 8 | |
TYMP | 0 | 0 | |||
TYK2 | 0 | 0 | |||
TXNRD1 | 0 | 0 | |||
TXNIP | 0 | 0 | |||
TWIST1 | 0 | 0 | |||
TUSC3 | 0 | 0 | |||
TUBG1 | 0 | 0 | |||
TUBE1 | 0 | 0 | |||
TUBD1 | 0 | 0 | |||
TUBB6 | 0 | 0 | |||
TUBB4B | 0 | 0 | |||
TUBB4A | 0 | 0 | |||
TUBB3 | 乳腺癌,癌症 | Taxane, | 紫杉醇, | 1 | 2 |
TUBB | 0 | 0 | |||
TUBA3C | 0 | 0 | |||
TUBA1A | 0 | 0 | |||
TTL | 0 | 0 | |||
TTF1 | 肺腺癌 | 1 | 1 | ||
TSPYL1 | 前列腺癌 | 1 | 1 | ||
TSN | 0 | 0 | |||
TSHZ3 | 0 | 0 | |||
TSHZ2 | 0 | 0 | |||
TSHR | 0 | 0 | |||
TSC2 | 肾细胞癌,甲状腺癌,结节性硬化 | 依维莫司,MTOR Inhibitors, | 2 | 3 | |
TSC1 | 膀胱癌,浸润性膀胱移行细胞癌,非小细胞肺癌,肾细胞癌,结节性硬化症 | 依维莫司,MTOR Inhibitors,西罗莫司, | 3 | 8 | |
TRRAP | 0 | 0 | |||
TRPS1 | 0 | 0 | |||
TRPC5 | 0 | 0 | |||
TRIO | 0 | 0 | |||
TRIM58 | 0 | 0 | |||
TRIM24 | 0 | 0 | |||
TRERF1 | 0 | 0 | |||
TRAP1 | 0 | 0 | |||
TRAF7 | 0 | 0 | |||
TRAF5 | 0 | 0 | |||
TRAF2 | 0 | 0 | |||
TRA2A | 0 | 0 | |||
TPX2 | 0 | 0 | |||
TPT1 | 黑色素瘤 | Sertraline (INN), | 1 | 1 | |
TPR | 0 | 0 | |||
TPMT | 0 | 0 | |||
TPM3 | 0 | 0 | |||
TPH1 | 0 | 0 | |||
TP73 | 0 | 0 | |||
TP63 | 0 | 0 | |||
TP53BP1 | 0 | 0 | |||
TP53 | 急性髓细胞白血病,肾上腺皮质癌,乳腺癌,癌症,宫颈癌,慢性淋巴细胞白血病,CLL/SLL,结直肠癌,食管癌,食管鳞状细胞癌,胃腺癌,头颈鳞状细胞癌,白血病,李夫琅梅尼综合征,肺腺癌癌细胞瘤,肺癌,非小细胞肺癌,淋巴瘤,骨髓增生异常综合征,骨髓瘤,神经母细胞瘤,少突胶质瘤,口腔鳞状细胞癌,卵巢癌,前体B淋巴细胞淋巴瘤/白血病,唾液腺粘液腺癌,肉瘤,皮肤鳞状细胞癌,胃癌胃癌,华登斯特巨球蛋白血症 | Adjuvant Chemotherapy,阿仑单抗,AMGMDS3,硼替佐米,卡培他滨,西妥昔单抗,Chemotherapy,EAP Protocol,Nutlin-3a,帕唑帕尼,培唑帕尼,RG7112,司美替尼,维莫非尼,维奈妥拉/维耐托克, | 卡铂,顺铂,多西他赛,多柔比星,依托泊苷,丝裂霉素,奥沙利铂,他莫昔芬, | 53 | 138 |
TOPBP1 | 0 | 0 | |||
TOP3A | 0 | 0 | |||
TOP2B | 0 | 0 | |||
TOP2A | 乳腺癌 | 多柔比星, | 1 | 1 | |
TOP1 | 结直肠癌,卵巢癌 | 卡铂,环磷酰胺,伊立替康,拓扑替康, | 2 | 3 | |
TOE1 | 0 | 0 | |||
TNRC18 | 0 | 0 | |||
TNR | 0 | 0 | |||
TNPO1 | 0 | 0 | |||
TNN | 0 | 0 | |||
TNKS2 | 0 | 0 | |||
TNKS | 0 | 0 | |||
TNK2 | 0 | 0 | |||
TNFSF13B | 0 | 0 | |||
TNFSF11 | 0 | 0 | |||
TNFRSF8 | 0 | 0 | |||
TNFRSF19 | 0 | 0 | |||
TNFRSF17 | 0 | 0 | |||
TNFRSF14 | 0 | 0 | |||
TNFRSF11A | 0 | 0 | |||
TNFAIP3 | 0 | 0 | |||
TNF | 0 | 0 | |||
TMPRSS2 | 0 | 0 | |||
TMPRSS15 | 0 | 0 | |||
TMEM67 | 0 | 0 | |||
TMEM132D | 0 | 0 | |||
TMEM127 | 0 | 0 | |||
TLX3 | 0 | 0 | |||
TLR4 | 0 | 0 | |||
TLL2 | 0 | 0 | |||
TLL1 | 0 | 0 | |||
TLK2 | 乳腺癌 | GF109203X,Go6983, | 1 | 1 | |
TLE1 | 0 | 0 | |||
TJP1 | 0 | 0 | |||
TIPARP | 0 | 0 | |||
TIMP1 | 乳腺癌 | 氟维司群, | 紫杉醇, | 1 | 2 |
TIMM8B | 0 | 0 | |||
TIE1 | 0 | 0 | |||
THRB | 0 | 0 | |||
THRAP3 | 0 | 0 | |||
THBS2 | 结直肠癌 | 1 | 1 | ||
THBS1 | 0 | 0 | |||
THADA | 0 | 0 | |||
TGM2 | 0 | 0 | |||
TGFBR3 | 前列腺癌 | 1 | 1 | ||
TGFBR2 | 0 | 0 | |||
TGFBR1 | 0 | 0 | |||
TGFB1 | 0 | 0 | |||
TGFA | 头颈部鳞状细胞癌 | 1 | 1 | ||
TG | 0 | 0 | |||
TFG | 0 | 0 | |||
TFF3 | 乳腺癌 | 氨鲁米特,他莫昔芬, | 1 | 1 | |
TFE3 | 0 | 0 | |||
TFDP2 | 0 | 0 | |||
TFDP1 | 0 | 0 | |||
TF | 黑色素瘤 | 维莫非尼, | 1 | 1 | |
TEX12 | 0 | 0 | |||
TET2 | 急性髓性白血病,骨髓增生异常综合征 | 1 | 6 | ||
TET1 | 0 | 0 | |||
TERT | Acral扁豆状黑色素瘤,脑胶质瘤,透明细胞肾细胞癌,多形胶质母细胞瘤,乳头状甲状腺癌,儿童低级别胶质瘤(PLGG),皮肤黑色素瘤,甲状腺癌 | I-131,U0126, | 5 | 15 | |
TERC | 0 | 0 | |||
TENT5C | 0 | 0 | |||
TENM3 | 0 | 0 | |||
TEKT4 | 0 | 0 | |||
TEK | 0 | 0 | |||
TECPR2 | 0 | 0 | |||
Tec | 0 | 0 | |||
TDO2 | 0 | 0 | |||
TDG | 0 | 0 | |||
TCP11 | 0 | 0 | |||
TCL1A | 0 | 0 | |||
TCF7L2 | 0 | 0 | |||
TCF4 | 0 | 0 | |||
TCF3 | 0 | 0 | |||
TCF12 | 0 | 0 | |||
TCERG1 | 0 | 0 | |||
TCEB1 | 0 | 0 | |||
TBX3 | 0 | 0 | |||
TBX22 | 0 | 0 | |||
TBX15 | 0 | 0 | |||
TBP | 0 | 0 | |||
TBL3 | 0 | 0 | |||
TBL1XR1 | 0 | 0 | |||
TBK1 | 黑色素瘤 | AZ909,司美替尼, | 1 | 1 | |
TBC1D8B | 0 | 0 | |||
TAP2 | 0 | 0 | |||
TAP1 | 0 | 0 | |||
TAL1 | 0 | 0 | |||
TAGAP | 0 | 0 | |||
TAF1L | 0 | 0 | |||
TAF15 | 0 | 0 | |||
TAF1 | 0 | 0 | |||
TACC3 | 0 | 0 | |||
TACC2 | 0 | 0 | |||
SYNE1 | 0 | 0 | |||
SYNCRIP | 0 | 0 | |||
SYK | 卵巢癌 | 紫杉醇, | 1 | 1 | |
SVEP1 | 0 | 0 | |||
SUZ12 | 0 | 0 | |||
SULT1A1 | 0 | 0 | |||
SUGCT | 0 | 0 | |||
SUFU | 髓母细胞瘤 | 索尼德吉, | 1 | 1 | |
SUCLG2 | 0 | 0 | |||
SUCLG1 | 0 | 0 | |||
SUB1 | 0 | 0 | |||
STT3A | 0 | 0 | |||
STRBP | 0 | 0 | |||
STMN1 | 子宫内膜癌 | 紫杉醇, | 1 | 1 | |
STK40 | 0 | 0 | |||
STK4 | 0 | 0 | |||
STK24 | 0 | 0 | |||
STK19 | 0 | 0 | |||
STK11 | 乳腺癌,肺腺癌,非小细胞肺癌,胰腺癌,Peutz-Jeghers综合征,前列腺癌 | CI-1040,依维莫司,依西美坦,派姆单抗(帕博利珠单抗),纳武单抗(纳武利尤单抗),阿特朱单抗,阿替利珠单抗,西罗莫司,SB202190,司美替尼,Sirolimus, | 多西他赛, | 7 | 17 |
STAT6 | 0 | 0 | |||
STAT5B | 0 | 0 | |||
STAT5A | 0 | 0 | |||
STAT4 | 0 | 0 | |||
STAT3 | T细胞大颗粒淋巴细胞白血病 | 1 | 1 | ||
STAT2 | 0 | 0 | |||
STAT1 | 0 | 0 | |||
STARD4 | 0 | 0 | |||
STAG3 | 黑色素瘤 | 维莫非尼, | 1 | 1 | |
STAG2 | 急性髓性白血病,膀胱癌,膀胱尿路上皮乳头状癌,骨尤因肉瘤,黑色素瘤 | 维莫非尼, | 2 | 5 | |
STAG1 | 0 | 0 | |||
ST6GALNAC3 | 0 | 0 | |||
ST6GAL2 | 0 | 0 | |||
ST3GAL3 | 0 | 0 | |||
SSX4 | 滑膜肉瘤 | 1 | 1 | ||
SSX2 | 滑膜肉瘤 | 1 | 4 | ||
SSX1 | 周围神经鞘恶性肿瘤,滑膜肉瘤 | 1 | 7 | ||
SSTR2 | 0 | 0 | |||
SS18 | 0 | 0 | |||
SRY | 0 | 0 | |||
SRSF7 | 0 | 0 | |||
SRSF2 | 急性髓性白血病 | 1 | 1 | ||
SRP19 | 0 | 0 | |||
SRMS | 0 | 0 | |||
SRGAP3 | 0 | 0 | |||
SRGAP1 | 0 | 0 | |||
SRD5A2 | 0 | 0 | |||
SRCAP | 0 | 0 | |||
SRC | 0 | 0 | |||
SPTA1 | 0 | 0 | |||
SPSB4 | 0 | 0 | |||
SPRY4 | 0 | 0 | |||
SPRY2 | 胃腺癌 | 1 | 1 | ||
SPRR3 | 0 | 0 | |||
SPRED1 | 0 | 0 | |||
SPOPL | 0 | 0 | |||
SPOP | 0 | 0 | |||
SPINK1 | 0 | 0 | |||
SPHKAP | 0 | 0 | |||
SPHK1 | 宫颈癌 | 1 | 1 | ||
SPG7 | 0 | 0 | |||
SPEN | 0 | 0 | |||
SPC24 | 0 | 0 | |||
SOX9 | 0 | 0 | |||
SOX4 | 0 | 0 | |||
SOX21 | 0 | 0 | |||
SOX2 | 0 | 0 | |||
SOX17 | 0 | 0 | |||
SOX14 | 0 | 0 | |||
SOX10 | 黑色素瘤 | 维莫非尼, | 1 | 1 | |
SOX1 | 0 | 0 | |||
SOS1 | 0 | 0 | |||
SORBS2 | 0 | 0 | |||
SOD2 | 0 | 0 | |||
SOCS1 | 0 | 0 | |||
SNX6 | 0 | 0 | |||
SNX29 | 0 | 0 | |||
SNTG1 | 0 | 0 | |||
SNCAIP | 0 | 0 | |||
SNAI2 | 0 | 0 | |||
SNAI1 | 0 | 0 | |||
SMYD3 | 0 | 0 | |||
SMURF2 | 0 | 0 | |||
SMO | 基底细胞癌,脑髓母细胞瘤,癌,非小细胞肺癌,髓母细胞瘤,脑膜瘤,嗅槽型脑膜瘤 | 吉非替尼,LDE225,PSI,Saridegib,维莫德吉, | 三氧化二砷, | 18 | 35 |
SMCHD1 | 0 | 0 | |||
SMC3 | 0 | 0 | |||
SMC1B | 0 | 0 | |||
SMC1A | 0 | 0 | |||
SMARCE1 | 0 | 0 | |||
SMARCD1 | 0 | 0 | |||
SMARCC2 | 0 | 0 | |||
SMARCC1 | 0 | 0 | |||
SMARCB1 | 横纹肌样癌,实体瘤,滑膜肉瘤 | 他泽司他,帕比司他,他泽司他, | 2 | 4 | |
SMARCAL1 | 0 | 0 | |||
SMARCA4 | 肺腺癌,非小细胞肺癌,卵巢小细胞癌,卵巢小细胞癌高钙型,实体瘤 | 玻玛西林,玻玛西尼,哌柏西利,帕博西尼,帕博西林,瑞博西尼,他泽司他,Tozasertib(MK-0457,VX-680), | 顺铂,长春瑞滨, | 4 | 8 |
SMARCA2 | 0 | 0 | |||
SMARCA1 | 0 | 0 | |||
SMAD7 | 0 | 0 | |||
SMAD4 | 结直肠癌,头颈鳞状细胞癌,青少年息肉综合征,非小细胞肺癌,胰腺腺癌,胰腺癌,胰管腺癌,前列腺癌 | 西妥昔单抗,帕尼单抗, | 氟尿嘧啶,吉西他滨,赖氨酸, | 7 | 15 |
SMAD3 | 0 | 0 | |||
SMAD2 | 0 | 0 | |||
SLX4 | 0 | 0 | |||
SLX1A | 0 | 0 | |||
SLITRK3 | 0 | 0 | |||
SLITRK2 | 0 | 0 | |||
SLITRK1 | 0 | 0 | |||
SLIT3 | 0 | 0 | |||
SLIT2 | 0 | 0 | |||
SLIT1 | 0 | 0 | |||
SLFN11 | 结直肠癌,尤因肉瘤,小细胞肺癌 | 尼拉帕尼,SN-38,他拉唑帕尼,替莫唑胺, | 1 | 3 | |
SLCO1B3 | 0 | 0 | |||
SLCO1B1 | 癌症 | 甲氨蝶呤, | 2 | 2 | |
SLC8A1 | 0 | 0 | |||
SLC7A8 | 0 | 0 | |||
SLC6A3 | 0 | 0 | |||
SLC4A1 | 0 | 0 | |||
SLC45A3 | 0 | 0 | |||
SLC45A2 | 0 | 0 | |||
SLC3A2 | 0 | 0 | |||
SLC34A2 | 0 | 0 | |||
SLC31A1 | 0 | 0 | |||
SLC30A5 | 0 | 0 | |||
SLC28A3 | 0 | 0 | |||
SLC22A4 | 0 | 0 | |||
SLC22A3 | 0 | 0 | |||
SLC22A2 | 0 | 0 | |||
SLC22A18 | 0 | 0 | |||
SLC22A16 | 0 | 0 | |||
SLC1A2 | 0 | 0 | |||
SLC19A1 | 0 | 0 | |||
SLC16A7 | 0 | 0 | |||
SLC16A1 | 0 | 0 | |||
SLC14A2 | 0 | 0 | |||
SLC10A2 | 0 | 0 | |||
SLAMF7 | 0 | 0 | |||
SKP2 | 0 | 0 | |||
SIX1 | 0 | 0 | |||
SIRT1 | 胰腺癌 | 烟酰胺, | 1 | 2 |