菜单 基因医生

该细胞周期调控基因编码一种蛋白质,介导富含亮氨酸的核输出信号(NES)依赖性蛋白质转运。该蛋白特异性地抑制rev和u-snrnas的核输出。它通过控制细胞周期蛋白B、MPAK和MAPKAP激酶2的定位,参与控制一些细胞过程。这种蛋白质还调节NFAT和AP-1。[由RefSeq提供,2015年1月]
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

基因名:XPO1
别名:emb,CRM1,exp1,CRM-1
基因ID:7514
Chromosome:
(GRCh37)
2 Start: 61705069 End: 61765440 Strand: 
信号通路: 细胞周期  肿瘤干细胞 
XPO1 基因突变与药物