菜单 基因医生

该基因编码一种核蛋白，调节转录延长和前mRNA剪接编码蛋白通过多个FF结构域与RNA聚合酶II的高磷酸化C端结构域相互作用，通过WW结构域与前mRNA剪接因子SF1相互作用选择性剪接导致编码不同亚型的多个转录变体。[由RefSeq提供，2008年7月]
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]