菜单 基因医生

该基因位于x染色体上,并受到x失活的影响。它在脊椎动物中高度保守,在大脑中表达最丰富。编码蛋白是组蛋白脱乙酰酶的一个组成部分,含有多蛋白复合物,通过改变染色质结构来保持基因沉默。涉及该基因的染色体易位(x;13)与x连锁认知障碍有关。已经发现了该基因的几种选择性剪接转录变体。[由RefSeq提供,2010年1月]
This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked cognitive disability. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010]

基因名:ZMYM3
别名:MYM,XFIM,ZNF261,DXS6673E,ZNF198L2
基因ID:9203
Chromosome:
(GRCh37)
X Start: 70459474 End: 70475047 Strand: 
信号通路:  
ZMYM3 基因突变与药物