菜单 基因医生

该基因属于TIS11家族的早期反应基因，由多种激动剂如佛波酯TPA和多肽丝裂原EGF诱导这个基因在不同物种间都很保守，并且有一个启动子，包含在其他早期反应基因中看到的基序。编码蛋白包含一个具有重复cys-his基序的锌指区。这种假定的核转录因子很可能在调节对生长因子的反应中发挥作用另外，已经发现该基因编码不同亚型的剪接转录变体[由RefSeq提供，2011年9月]
This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]