菜单 基因医生

泛素修饰蛋白质是一种重要的细胞机制，可以靶向异常或短寿命蛋白质的降解泛素化至少涉及三类酶：泛素激活酶，或E1s，泛素结合酶，或E2s，和泛素蛋白连接酶，或E3s。这个基因编码一个E2泛素结合酶家族的成员所编码的蛋白与小鼠和大鼠的对应蛋白具有100%的序列一致性，表明该酶在真核生物中高度保守。已发现该基因的多个编码相同蛋白质的选择性剪接转录变体。[由RefSeq提供，2013年6月]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]