菜单 基因医生

该基因属于瞬时受体家族。它编码七种哺乳动物TRPC(瞬时受体电位通道)蛋白之一编码蛋白是一种多道膜蛋白,被认为是一种受体激活的非选择性钙离子通道该蛋白单独或与trpc1、trpc3和trpc4作为异多聚体组装而具有活性。它还与多种蛋白质相互作用,包括钙调素、CABP1、enkurin、Na+-H+交换调节因子(NHERF)、干扰素诱导的GTP结合蛋白(MX1)、无名指蛋白24(RNF24)和含有SEC14结构域和谱蛋白重复序列的蛋白1(SESTD1)[由RefSeq提供,2010年5月]
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]

基因名:TRPC5
别名:TRP5,PPP1R159
基因ID:7224
Chromosome:
(GRCh37)
X Start: 111017542 End: 111326004 Strand: 
信号通路:  
TRPC5 基因突变与药物