菜单 基因医生

该基因的产物是一种丝裂原诱导的gtpase激活蛋白(gap)。它对ras相关的调节蛋白rap1和rap2表现出特异的gap活性,但对ran或其他小gtpase则没有。当异常或过早表达时,这种蛋白也可能阻碍有丝分裂原诱导的细胞周期进程。它局限于核周区迄今为止,已经对编码相同亚型的两个交替拼接变体进行了表征。[由RefSeq提供,2008年7月]
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

基因名:SIPA1
别名:SPA1
基因ID:6494
Chromosome:
(GRCh37)
11 Start: 65405578 End: 65418391 Strand: 
信号通路:  
SIPA1 基因突变与药物