菜单 基因医生

由该基因编码的dna相关蛋白是定位于细胞核的同源盒蛋白成对家族的成员。该蛋白作为转录辅激活剂,增强血清应答因子(生长和分化因子诱导基因所需的蛋白质)的dna结合活性。该蛋白调节肌肉肌酸激酶,表明在建立不同的中胚层肌肉类型的作用。选择性剪接产生两种在丰度和表达模式上不同的亚型。[由RefSeq提供,2008年7月]
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008]

基因名:PRRX1
别名:PMX1,PRX1,AGOTC,PHOX1,PRX-1
基因ID:5396
Chromosome:
(GRCh37)
1 Start: 170633313 End: 170708541 Strand: 
信号通路:  
PRRX1 基因突变与药物