菜单 基因医生

该基因编码磷脂酶A2（PLA2）类酶的分泌成员，由胰腺腺泡细胞产生编码的钙依赖性酶催化膜磷脂sn-2位水解释放花生四烯酸（aa）和溶血磷脂。aa随后被下游代谢酶转化为多种生物活性亲脂化合物（二十碳），包括前列腺素（pgs）和白三烯（lts）。该酶可能参与多种生理过程，包括细胞收缩、细胞增殖和病理反应。[由RefSeq提供，2013年8月]
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]