菜单 基因医生

该基因编码的蛋白属于磷酸肌醇3激酶（PI3K）家族pi3激酶在参与细胞增殖、癌基因转化、细胞存活、细胞迁移和细胞内蛋白质转运的信号传导途径中发挥作用。该蛋白包含一个脂质激酶催化结构域和一个C末端C2结构域，这是II类PI3激酶的特征C2结构域作为钙依赖性磷脂结合基序，介导蛋白质向膜的转运，也可能介导蛋白质-蛋白质的相互作用。该蛋白的pi3激酶活性对抑制剂wortmanin的纳摩尔水平不敏感。该蛋白能被胰岛素激活，可能参与整合素依赖信号传导。[由RefSeq提供，2008年7月]
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]