菜单 基因医生

精子发生是一个复杂的过程，受细胞外和细胞内因素以及睾丸间质细胞、支持细胞和生殖细胞之间的细胞相互作用的调节。这个基因在睾丸的支持细胞中表达，而不是生殖细胞该基因编码的蛋白质包含植物同源结构域（phd）指状结构域，也被称为白血病相关蛋白（lap）结构域，被认为参与转录调控。该蛋白定位于转染细胞的细胞核，参与了精子发生的转录调控。交替剪接导致该基因的多个转录变体。[由RefSeq提供，2013年5月]
Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]