菜单 基因医生

这个无内含子的基因被认为是由一个完全处理过的pcbp-2mrna的反转录产生的。这个基因和PCBP-2有副作用（PCBP3和PCBP4），被认为是由于整个基因的重复事件而产生的这个基因编码的蛋白质似乎是多功能的。它与pcbp-2和hnrnpk一起对应于主要的细胞聚（rc）结合蛋白。它包含三个可能参与RNA结合的K-同源（KH）结构域该编码蛋白与pcbp-2还通过与ires茎环iv的序列特异性相互作用，作为脊髓灰质炎病毒rna的翻译辅活化子，并通过与5'-末端三叶草结构结合促进脊髓灰质炎病毒rna的复制。它还与15脂氧合酶mrna、人乳头瘤病毒16l2mrna和甲型肝炎病毒rna的翻译控制有关。该编码蛋白也被认为参与了序列特异性α珠蛋白mrnp复合物的形成，该复合物与α珠蛋白mrna的稳定性有关。[由RefSeq提供，2008年7月]
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]