菜单 基因医生

该基因编码一个p21刺激的丝氨酸/苏氨酸蛋白激酶家族成员，该家族包含一个氨基末端cdc42/rac相互作用结合（crib）结构域和一个羧基末端激酶结构域。这些激酶在许多细胞过程中发挥作用，包括细胞骨架重排、细胞凋亡和丝裂原活化蛋白激酶信号途径。该基因编码的蛋白质与雄激素受体（ar）相互作用并转运到细胞核，参与转录调控。这种基因表达的变化与前列腺癌有关。选择性剪接导致多个转录变体。[由RefSeq提供，2015年12月]
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]