DNA的双链断裂是由遗传毒性应激引起的，是DNA损伤最严重的损伤之一。该基因编码非同源末端连接途径所必需的dna修复因子，该因子优先介导双链断裂的修复。这种基因的突变会导致不同类型的严重联合免疫缺陷疾病。[由RefSeq提供，2008年7月]
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008]
| 基因名： | NHEJ1 |
| 别名： | XLF |
| 基因ID： | 79840 |
| Chromosome： (GRCh37) | 2 Start: 219940046 End: 220025587 Strand: |
| 信号通路： |
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