菜单 基因医生

该基因编码一种蛋白质，该蛋白质包含一个能与血管紧张素ii（at2）受体相互作用的c末端结构域和一个允许二聚的大卷曲线圈区域。已经发现该基因的多个交替剪接的转录变体编码不同的亚型。其中一个转录变体被证明编码一种线粒体蛋白，作为肿瘤抑制因子并参与AT2信号通路。其他变异可能编码核蛋白或跨膜蛋白，但尚未确定它们是否也参与at2信号通路。[由RefSeq提供，2008年7月]
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]