菜单 基因医生

该基因编码一个与erk1和p38丝裂原激活蛋白激酶相互作用并被其激活的ser/thr蛋白激酶,因此可能在环境应激和细胞因子反应中发挥作用。该激酶也可以通过与eif4g的c末端区域相互作用来磷酸化eif4e来调节转录。另外,该基因的剪接转录变体已经被发现。[由RefSeq提供,2012年1月]
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

基因名:MKNK1
别名:MNK1
基因ID:8569
Chromosome:
(GRCh37)
1 Start: 47023079 End: 47069966 Strand: 
信号通路:  
MKNK1 基因突变与药物