菜单 基因医生

电压门控钾（kv）通道从功能和结构上都代表了电压门控离子通道中最复杂的一类。它们的多种功能包括调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积。在果蝇中发现了四个与钾通道相关的基因，分别是shaker、shaw、shab和shal，并且每个基因都有人类同源基因该基因编码钾通道的一个成员，电压门控，shal相关亚家族，其成员形成电压激活的a型钾离子通道，在动作电位的复极期表现突出该成员介导一种快速失活的，a型外向钾电流，它不受N端的控制，因为它是在摇床通道[由RefSeq提供，2008年7月]
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]