菜单 基因医生

导入蛋白α/β复合物和gtpase ran通过经典的核定位信号介导蛋白质的核导入。由该基因编码的蛋白质是一类约20个潜在的RAN靶的成员，它们共享与导入蛋白β的RAN结合位点相关的序列基序。与importinβ类似，该蛋白阻止RanGAP1激活Ran的GTPase，并抑制RanGTP上的核苷酸交换，还直接与核孔复合体结合，在那里它与importinβ和transportin竞争结合位点这种蛋白质有一个依赖于Ran的运输循环，它可以快速地在两个方向穿过核膜至少有四种导入蛋白β样转运受体，即导入蛋白β自身、转运蛋白、RanBP5和RanBP7，直接结合和导入核糖体蛋白[由RefSeq提供，2008年7月]
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]