菜单 基因医生

组蛋白是构成真核生物染色体纤维核小体结构的基本核蛋白该结构由包裹在核小体周围的约146 bp的DNA组成，由四个核心组蛋白（H2A、H2B、H3和H4）中的每一个组成的八聚体组成。染色质纤维通过连接组蛋白h1与核小体之间的dna相互作用进一步紧密，形成高阶染色质结构。该基因无内含子，编码一个复制依赖性组蛋白，是组蛋白h3家族的成员。这个基因的转录本没有polya尾；相反，它们包含一个回文终止元素。该基因存在于6p22-p21.3号染色体上的大组蛋白基因簇中。[由RefSeq提供，2015年8月]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]