菜单 基因医生

谷胱甘肽s-转移酶的胞浆和膜结合形式由两个不同的表基因家族编码。目前，已鉴定出8种不同类型的可溶性哺乳动物细胞质谷胱甘肽s-转移酶：α、kappa、mu、omega、pi、sigma、theta和zeta。该基因编码属于mu类的谷胱甘肽s-转移酶。μ类酶在亲电化合物的解毒中起作用，包括与谷胱甘肽结合的致癌物、治疗药物、环境毒素和氧化应激产物。编码mu类酶的基因在1p13.3号染色体上形成一个基因簇，具有高度多态性。这些遗传变异可以改变个体对致癌物和毒素的易感性，并影响某些药物的毒性和功效。该类MU基因的空突变与许多癌症的增加有关，这可能是由于对环境毒素和致癌物的易感性增加所致。多个蛋白质亚型由该基因的转录变体编码。[由RefSeq提供，2008年7月]
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]