菜单 基因医生

该基因编码一种DNA解缠酶,该酶偏好部分解缠的3’-尾底物,也能以ATP依赖的方式解缠部分RNA/DNA和RNA/RNA双工这种酶是异质核RNA结合蛋白的一个成员,也是Ras信号转导途径的一个组成部分它通过与SH3结构域结合,特异性地与Ras GTPase激活蛋白结合已经描述了该基因的几个选择性剪接的转录变体,但其中一些变体的全长性质尚未确定。[由RefSeq提供,2008年7月]
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

基因名:G3BP1
别名:G3BP,HDH-VIII
基因ID:10146
Chromosome:
(GRCh37)
5 Start: 151151476 End: 151184915 Strand: 
信号通路:  
G3BP1 基因突变与药物