菜单 基因医生

这个基因编码的蛋白质是E2F转录因子家族的一员。e2f家族在调控细胞周期和抑癌蛋白的作用中起着关键作用，也是小dna肿瘤病毒转化蛋白的靶点。E2F蛋白包含几个进化上保守的结构域，发现于该家族的大多数成员中这些结构域包括dna结合结构域、决定与分化调节转录因子蛋白（dp）相互作用的二聚结构域、富含酸性氨基酸的反式激活结构域和嵌入在反式激活结构域中的抑癌蛋白关联结构域。这个蛋白和另外两个成员，E2F2和E2F3，有一个额外的细胞周期蛋白结合结构域。该蛋白以细胞周期依赖的方式优先与视网膜母细胞瘤蛋白prb结合。它能介导细胞增殖和p53依赖性/非依赖性凋亡[由RefSeq提供，2008年7月]
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]