菜单 基因医生

这个基因是卡林家族的一员。编码的蛋白质形成一个复合物，作为e3泛素连接酶发挥作用，并催化细胞中特定蛋白质底物的多泛素化。该蛋白与无名指蛋白相互作用，是dna复制的几个调节因子（包括染色质许可、dna复制因子1和细胞周期蛋白e）的蛋白水解所必需的。已发现该基因的多个转录变体编码不同的亚型。[由RefSeq提供，2008年7月]
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]