菜单 基因医生

由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族，其成员在整个细胞周期中的蛋白质丰度具有显著的周期性。细胞周期蛋白是细胞周期蛋白依赖性激酶（CDKs）的阳性调节因子，在细胞周期调控中起着重要作用不同的细胞周期蛋白表现出不同的表达和降解模式，这有助于每个有丝分裂事件的时间协调。对鸡和果蝇相似基因的研究表明，这种细胞周期蛋白可能与cdc2和cdk2激酶有关，可能是纺锤体重组和间期细胞核修复的必需条件。另外，编码不同亚型的剪接转录变体已经被描述为该基因[由RefSeq提供，2011年10月]
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]