菜单 基因医生

由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族，其成员在整个细胞周期中的蛋白质丰度具有显著的周期性。细胞周期蛋白是cdk激酶的调节因子。不同的细胞周期蛋白表现出不同的表达和降解模式，这有助于每个有丝分裂事件的时间协调。由该基因编码的细胞周期蛋白在睾丸和大脑以及一些白血病细胞系中均有表达，被认为主要在生殖系减数分裂细胞周期的控制中起作用。这种细胞周期蛋白结合CDK2和CDC2两种激酶，它们产生两种不同的激酶活性，一种出现在S期，另一种出现在G2期，从而调节细胞周期中的不同功能该细胞周期蛋白被发现与重要的细胞周期调控因子结合，如rb家族蛋白、转录因子e2f-1和p21家族蛋白。已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供，2008年7月]
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]