菜单 基因医生

该基因产物属于丝氨酸/苏氨酸蛋白激酶家族，属于钙/钙调素依赖蛋白激酶亚家族。该基因的主要亚型通过磷酸化下游激酶CaMK1和CaMK4在钙/钙调素依赖（CaM）激酶级联中起作用该基因的蛋白产物也磷酸化AMP活化蛋白激酶（AMPK）。该基因在大脑中表达最强，并影响与学习和记忆、神经元分化和迁移、神经突起生长和突触形成有关的信号级联。选择性剪接导致编码不同亚型的多个转录变体。所鉴定的亚型在经历自磷酸化和磷酸化下游激酶的能力上不同。[由RefSeq提供，2012年7月]
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]