菜单 基因医生

这个基因编码一个转录抑制物，它与BCL2家族的几个成员相互作用。该蛋白的过度表达可诱导细胞凋亡，bcl2蛋白的共同表达可抑制细胞凋亡。这种蛋白质在整个细胞核内定位成点状结构，并在细胞凋亡过程中重新分布到核膜附近的区域已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供，2008年7月]
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]