菜单 基因医生

该基因是原癌基因候选基因在某些B细胞白血病病例中，它通过转移到免疫球蛋白α位点而被识别。该基因编码的蛋白质含有七个锚蛋白重复序列，它们与i-kappa b蛋白最为密切相关。该蛋白通过与nf-kappa b同源二聚体的结合起转录辅激活作用。NF-kappa B可以诱导该基因的表达，它构成了控制p50-NF-kappab核居住地的自我调节回路的一部分
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]