菜单 基因医生

该基因编码一种与视网膜母细胞瘤结合蛋白-1序列相似的蛋白质编码蛋白是组蛋白去乙酰化酶依赖的SIN3A转录辅压蛋白复合物的一个亚单位，在多种细胞过程中发挥作用，包括增殖、分化、凋亡、癌变和细胞命运的决定该基因产物被从乳腺癌患者中分离出来的IgG抗体识别，似乎是一种与多种人类恶性肿瘤相关的分子标记已鉴定出编码不同亚型的交替转录剪接变体。[由RefSeq提供，2008年7月]
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]