| 基因名 | 疾病 | 靶向药 | 化疗药 | 基因突变 | 临床解释 |
|---|---|---|---|---|---|
| RMI2 | 0 | 0 | |||
| RNASEL | 0 | 0 | |||
| RNF19A | 0 | 0 | |||
| RNF213 | 0 | 0 | |||
| RNF43 | 0 | 0 | |||
| ROBO1 | 0 | 0 | |||
| ROBO2 | 0 | 0 | |||
| ROBO3 | 0 | 0 | |||
| ROBO4 | 癌症 | Antiangiogenic Therapy, | 1 | 1 | |
| ROCK1 | 0 | 0 | |||
| ROCK2 | 0 | 0 | |||
| ROS1 | 支气管肺泡腺癌,癌,大肠癌,多形胶质母细胞瘤,炎性肌成纤维细胞瘤,肺腺癌,非小细胞肺癌 | AZD3463,布加替尼,卡博替尼,色瑞替尼，塞瑞替尼,克唑替尼,恩曲替尼,Foretinib,吉非替尼,劳拉替尼,TAE684, | 12 | 31 | |
| RP1L1 | 0 | 0 | |||
| RPA1 | 0 | 0 | |||
| RPA4 | 0 | 0 | |||
| RPGR | 0 | 0 | |||
| RPL11 | 0 | 0 | |||
| RPL22 | 0 | 0 | |||
| RPL35A | 0 | 0 | |||
| RPL5 | 0 | 0 | |||
| RPP30 | 0 | 0 | |||
| RPS10 | 0 | 0 | |||
| RPS14 | 0 | 0 | |||
| RPS17 | 0 | 0 | |||
| RPS19 | 0 | 0 | |||
| RPS24 | 0 | 0 | |||
| RPS26 | 0 | 0 | |||
| RPS29 | 0 | 0 | |||
| RPS6 | 胃腺癌 | 依维莫司, | 1 | 1 | |
| RPS6KA1 | 0 | 0 | |||
| RPS6KA3 | 0 | 0 | |||
| RPS6KA4 | 0 | 0 | |||
| RPS6KB1 | 0 | 0 | |||
| RPS6KB2 | 0 | 0 | |||
| RPS7 | 0 | 0 | |||
| RPTOR | 0 | 0 | |||
| RRAGC | 0 | 0 | |||
| RRAS | 0 | 0 | |||
| RRAS2 | 0 | 0 | |||
| RRM1 | 非小细胞肺癌,胰腺癌 | Cisplatine,PLATINUM, | 顺铂,多西他赛,吉西他滨,吉西他滨,顺铂,紫杉醇,长春瑞滨, | 2 | 9 |
| RRM2 | 胰腺癌 | 吉西他滨, | 1 | 1 | |
| RRP1B | 0 | 0 | |||
| RSF1 | 乳腺癌 | 他莫昔芬, | 1 | 1 | |
| RSPO2 | 0 | 0 | |||
| RSPO3 | 0 | 0 | |||
| RTEL1 | 0 | 0 | |||
| RUFY4 | 0 | 0 | |||
| RUNX1 | 急性淋巴细胞性白血病,急性髓性白血病,骨髓增生异常综合征 | 阿糖胞苷, | 7 | 13 | |
| RUNX1T1 | 0 | 0 | |||
| RUNX2 | 0 | 0 | |||
| RUNX3 | 0 | 0 | |||
| RXRA | 0 | 0 | |||
| RXRB | 0 | 0 | |||
| RXRG | 0 | 0 | |||
| RYBP | 0 | 0 | |||
| RYR1 | 0 | 0 | |||
| RYR2 | 0 | 0 | |||
| RYR3 | 0 | 0 | |||
| SALL1 | 0 | 0 | |||
| SAMD9 | 0 | 0 | |||
| SASH1 | 0 | 0 | |||
| SATB2 | 0 | 0 | |||
| SBDS | 0 | 0 | |||
| SBNO2 | 0 | 0 | |||
| SCG5 | 0 | 0 | |||
| SCN8A | 肺腺癌 | 派姆单抗（帕博利珠单抗）, | 1 | 1 | |
| SCUBE2 | 0 | 0 | |||
| SDC4 | 0 | 0 | |||
| SDCCAG8 | 0 | 0 | |||
| SDHA | 0 | 0 | |||
| SDHAF2 | 0 | 0 | |||
| SDHB | 副神经节瘤 | 1 | 1 | ||
| SDHC | 0 | 0 | |||
| SDHD | 0 | 0 | |||
| SEC31A | 0 | 0 | |||
| SEL1L3 | 0 | 0 | |||
| SEMA3A | 0 | 0 | |||
| SEMA3C | 0 | 0 | |||
| SEMA3E | 0 | 0 | |||
| SEMA6A | 0 | 0 | |||
| Sept14 | 0 | 0 | |||
| Sept9 | 0 | 0 | |||
| SERP2 | 0 | 0 | |||
| SERPINA7 | 0 | 0 | |||
| SERPINB3 | 0 | 0 | |||
| SERPINB4 | 0 | 0 | |||
| SESN1 | 0 | 0 | |||
| SESN2 | 0 | 0 | |||
| SESN3 | 0 | 0 | |||
| SETBP1 | 慢性粒细胞白血病,少年粒细胞白血病 | 3 | 3 | ||
| SETD2 | 0 | 0 | |||
| SETDB1 | 0 | 0 | |||
| SETMAR | 0 | 0 | |||
| SF1 | 0 | 0 | |||
| SF3A1 | 0 | 0 | |||
| SF3A3 | 0 | 0 | |||
| SF3B1 | 乳腺癌,慢性淋巴细胞白血病,骨髓增生异常综合征 | Spliceostatin A, | 3 | 9 | |
| SFPQ | 0 | 0 | |||
| SFXN4 | 0 | 0 | |||
| SGCZ | 0 | 0 | |||
| SGK1 | 乳腺癌 | 阿培利司,SGK1-Inh, | 1 | 3 | |
| SH2B3 | 结直肠癌 | 1 | 1 | ||
| SH2D1A | 0 | 0 | |||
| SH2D2A | 0 | 0 | |||
| SH3PXD2A | 0 | 0 | |||
| SHBG | 0 | 0 | |||
| SHH | 0 | 0 | |||
| SHMT1 | 0 | 0 | |||
| SHOC2 | 0 | 0 | |||
| SHPRH | 0 | 0 | |||
| SHQ1 | 0 | 0 | |||
| SHROOM3 | 0 | 0 | |||
| SI | 0 | 0 | |||
| SIK1 | 0 | 0 | |||
| SIMC1 | 0 | 0 | |||
| SIN3A | 0 | 0 | |||
| SIPA1 | 0 | 0 | |||
| SIPA1L2 | 0 | 0 | |||
| SIRT1 | 胰腺癌 | 烟酰胺, | 1 | 2 | |
| SIX1 | 0 | 0 | |||
| SKP2 | 0 | 0 | |||
| SLAMF7 | 0 | 0 | |||
| SLC10A2 | 0 | 0 | |||
| SLC14A2 | 0 | 0 | |||
| SLC16A1 | 0 | 0 | |||
| SLC16A7 | 0 | 0 | |||
| SLC19A1 | 0 | 0 | |||
| SLC1A2 | 0 | 0 | |||
| SLC22A16 | 0 | 0 | |||
| SLC22A18 | 0 | 0 | |||
| SLC22A2 | 0 | 0 | |||
| SLC22A3 | 0 | 0 | |||
| SLC22A4 | 0 | 0 | |||
| SLC28A3 | 0 | 0 | |||
| SLC30A5 | 0 | 0 | |||
| SLC31A1 | 0 | 0 | |||
| SLC34A2 | 0 | 0 | |||
| SLC3A2 | 0 | 0 | |||
| SLC45A2 | 0 | 0 | |||
| SLC45A3 | 0 | 0 | |||
| SLC4A1 | 0 | 0 | |||
| SLC6A3 | 0 | 0 | |||
| SLC7A8 | 0 | 0 | |||
| SLC8A1 | 0 | 0 | |||
| SLCO1B1 | 癌症 | 甲氨蝶呤, | 2 | 2 | |
| SLCO1B3 | 0 | 0 | |||
| SLFN11 | 结直肠癌,尤因肉瘤,小细胞肺癌 | 尼拉帕尼,SN-38,他拉唑帕尼,替莫唑胺, | 1 | 3 | |
| SLIT1 | 0 | 0 | |||
| SLIT2 | 0 | 0 | |||
| SLIT3 | 0 | 0 | |||
| SLITRK1 | 0 | 0 | |||
| SLITRK2 | 0 | 0 | |||
| SLITRK3 | 0 | 0 | |||
| SLX1A | 0 | 0 | |||
| SLX4 | 0 | 0 | |||
| SMAD2 | 0 | 0 | |||
| SMAD3 | 0 | 0 | |||
| SMAD4 | 结直肠癌,头颈鳞状细胞癌,青少年息肉综合征,非小细胞肺癌,胰腺腺癌,胰腺癌,胰管腺癌,前列腺癌 | 西妥昔单抗,帕尼单抗, | 氟尿嘧啶,吉西他滨,赖氨酸, | 7 | 15 |
| SMAD7 | 0 | 0 | |||
| SMARCA1 | 0 | 0 | |||
| SMARCA2 | 0 | 0 | |||
| SMARCA4 | 肺腺癌,非小细胞肺癌,卵巢小细胞癌,卵巢小细胞癌高钙型,实体瘤 | 玻玛西林,玻玛西尼,哌柏西利,帕博西尼,帕博西林,瑞博西尼,他泽司他,Tozasertib(MK-0457,VX-680), | 顺铂,长春瑞滨, | 4 | 8 |
| SMARCAL1 | 0 | 0 | |||
| SMARCB1 | 横纹肌样癌,实体瘤,滑膜肉瘤 | 他泽司他,帕比司他,他泽司他, | 2 | 4 | |
| SMARCC1 | 0 | 0 | |||
| SMARCC2 | 0 | 0 | |||
| SMARCD1 | 0 | 0 | |||
| SMARCE1 | 0 | 0 | |||
| SMC1A | 0 | 0 | |||
| SMC1B | 0 | 0 | |||
| SMC3 | 0 | 0 | |||
| SMCHD1 | 0 | 0 | |||
| SMO | 基底细胞癌,脑髓母细胞瘤,癌,非小细胞肺癌,髓母细胞瘤,脑膜瘤,嗅槽型脑膜瘤 | 吉非替尼,LDE225,PSI,Saridegib,维莫德吉, | 三氧化二砷, | 18 | 35 |
| SMURF2 | 0 | 0 | |||
| SMYD3 | 0 | 0 | |||
| SNAI1 | 0 | 0 | |||
| SNAI2 | 0 | 0 | |||
| SNCAIP | 0 | 0 | |||
| SNTG1 | 0 | 0 | |||
| SNX29 | 0 | 0 | |||
| SNX6 | 0 | 0 | |||
| SOCS1 | 0 | 0 | |||
| SOD2 | 0 | 0 | |||
| SORBS2 | 0 | 0 | |||
| SOS1 | 0 | 0 | |||
| SOX1 | 0 | 0 | |||
| SOX10 | 黑色素瘤 | 维莫非尼, | 1 | 1 | |
| SOX14 | 0 | 0 | |||
| SOX17 | 0 | 0 | |||
| SOX2 | 0 | 0 | |||
| SOX21 | 0 | 0 | |||
| SOX4 | 0 | 0 | |||
| SOX9 | 0 | 0 | |||
| SPC24 | 0 | 0 | |||
| SPEN | 0 | 0 | |||
| SPG7 | 0 | 0 | |||
| SPHK1 | 宫颈癌 | 1 | 1 | ||
| SPHKAP | 0 | 0 | |||
| SPINK1 | 0 | 0 | |||
| SPOP | 0 | 0 | |||
| SPOPL | 0 | 0 | |||
| SPRED1 | 0 | 0 | |||
| SPRR3 | 0 | 0 | |||
| SPRY2 | 胃腺癌 | 1 | 1 | ||
| SPRY4 | 0 | 0 | |||
| SPSB4 | 0 | 0 | |||
| SPTA1 | 0 | 0 | |||
| SRC | 0 | 0 | |||
| SRCAP | 0 | 0 | |||
| SRD5A2 | 0 | 0 | |||
| SRGAP1 | 0 | 0 | |||
| SRGAP3 | 0 | 0 | |||
| SRMS | 0 | 0 | |||
| SRP19 | 0 | 0 | |||
| SRSF2 | 急性髓性白血病 | 1 | 1 | ||
| SRSF7 | 0 | 0 | |||
| SRY | 0 | 0 | |||
| SS18 | 0 | 0 | |||
| SSTR2 | 0 | 0 | |||
| SSX1 | 周围神经鞘恶性肿瘤,滑膜肉瘤 | 1 | 7 | ||
| SSX2 | 滑膜肉瘤 | 1 | 4 | ||
| SSX4 | 滑膜肉瘤 | 1 | 1 | ||
| ST3GAL3 | 0 | 0 | |||
| ST6GAL2 | 0 | 0 | |||
| ST6GALNAC3 | 0 | 0 | |||
| STAG1 | 0 | 0 | |||
| STAG2 | 急性髓性白血病,膀胱癌,膀胱尿路上皮乳头状癌,骨尤因肉瘤,黑色素瘤 | 维莫非尼, | 2 | 5 | |
| STAG3 | 黑色素瘤 | 维莫非尼, | 1 | 1 | |
| STARD4 | 0 | 0 | |||
| STAT1 | 0 | 0 | |||
| STAT2 | 0 | 0 | |||
| STAT3 | T细胞大颗粒淋巴细胞白血病 | 1 | 1 | ||
| STAT4 | 0 | 0 | |||
| STAT5A | 0 | 0 | |||
| STAT5B | 0 | 0 | |||
| STAT6 | 0 | 0 | |||
| STK11 | 乳腺癌,肺腺癌,非小细胞肺癌,胰腺癌,Peutz-Jeghers综合征,前列腺癌 | CI-1040,依维莫司,依西美坦,派姆单抗（帕博利珠单抗）,纳武单抗（纳武利尤单抗）,阿特朱单抗，阿替利珠单抗,西罗莫司,SB202190,司美替尼,Sirolimus, | 多西他赛, | 7 | 17 |
| STK19 | 0 | 0 | |||
| STK24 | 0 | 0 | |||
| STK4 | 0 | 0 | |||
| STK40 | 0 | 0 | |||
| STMN1 | 子宫内膜癌 | 紫杉醇, | 1 | 1 | |
| STRBP | 0 | 0 | |||
| STT3A | 0 | 0 | |||
| SUB1 | 0 | 0 | |||
| SUCLG1 | 0 | 0 | |||
| SUCLG2 | 0 | 0 | |||
| SUFU | 髓母细胞瘤 | 索尼德吉, | 1 | 1 | |
| SUGCT | 0 | 0 | |||
| SULT1A1 | 0 | 0 | |||
| SUZ12 | 0 | 0 | |||
| SVEP1 | 0 | 0 | |||
| SYK | 卵巢癌 | 紫杉醇, | 1 | 1 | |
| SYNCRIP | 0 | 0 | |||
| SYNE1 | 0 | 0 | |||
| TACC2 | 0 | 0 | |||
| TACC3 | 0 | 0 | |||
| TAF1 | 0 | 0 | |||
| TAF15 | 0 | 0 | |||
| TAF1L | 0 | 0 | |||
| TAGAP | 0 | 0 | |||
| TAL1 | 0 | 0 | |||
| TAP1 | 0 | 0 | |||
| TAP2 | 0 | 0 | |||
| TBC1D8B | 0 | 0 | |||
| TBK1 | 黑色素瘤 | AZ909,司美替尼, | 1 | 1 | |
| TBL1XR1 | 0 | 0 | |||
| TBL3 | 0 | 0 | |||
| TBP | 0 | 0 | |||
| TBX15 | 0 | 0 | |||
| TBX22 | 0 | 0 | |||
| TBX3 | 0 | 0 | |||
| TCEB1 | 0 | 0 | |||
| TCERG1 | 0 | 0 | |||
| TCF12 | 0 | 0 | |||
| TCF3 | 0 | 0 | |||
| TCF4 | 0 | 0 | |||
| TCF7L2 | 0 | 0 | |||
| TCL1A | 0 | 0 | |||
| TCP11 | 0 | 0 | |||
| TDG | 0 | 0 | |||
| TDO2 | 0 | 0 | |||
| Tec | 0 | 0 | |||
| TECPR2 | 0 | 0 | |||
| TEK | 0 | 0 | |||
| TEKT4 | 0 | 0 | |||
| TENM3 | 0 | 0 | |||
| TENT5C | 0 | 0 | |||
| TERC | 0 | 0 | |||
| TERT | Acral扁豆状黑色素瘤,脑胶质瘤,透明细胞肾细胞癌,多形胶质母细胞瘤,乳头状甲状腺癌,儿童低级别胶质瘤（PLGG）,皮肤黑色素瘤,甲状腺癌 | I-131,U0126, | 5 | 15 | |
| TET1 | 0 | 0 | |||
| TET2 | 急性髓性白血病,骨髓增生异常综合征 | 1 | 6 | ||
| TEX12 | 0 | 0 | |||
| TF | 黑色素瘤 | 维莫非尼, | 1 | 1 | |
| TFDP1 | 0 | 0 | |||
| TFDP2 | 0 | 0 | |||
| TFE3 | 0 | 0 | |||
| TFF3 | 乳腺癌 | 氨鲁米特,他莫昔芬, | 1 | 1 | |
| TFG | 0 | 0 | |||
| TG | 0 | 0 | |||
| TGFA | 头颈部鳞状细胞癌 | 1 | 1 | ||
| TGFB1 | 0 | 0 | |||
| TGFBR1 | 0 | 0 | |||
| TGFBR2 | 0 | 0 | |||
| TGFBR3 | 前列腺癌 | 1 | 1 | ||
| TGM2 | 0 | 0 | |||
| THADA | 0 | 0 | |||
| THBS1 | 0 | 0 | |||
| THBS2 | 结直肠癌 | 1 | 1 | ||
| THRAP3 | 0 | 0 | |||
| THRB | 0 | 0 | |||
| TIE1 | 0 | 0 | |||
| TIMM8B | 0 | 0 | |||
| TIMP1 | 乳腺癌 | 氟维司群, | 紫杉醇, | 1 | 2 |
| TIPARP | 0 | 0 | |||
| TJP1 | 0 | 0 | |||
| TLE1 | 0 | 0 | |||
| TLK2 | 乳腺癌 | GF109203X,Go6983, | 1 | 1 | |
| TLL1 | 0 | 0 | |||
| TLL2 | 0 | 0 | |||
| TLR4 | 0 | 0 | |||
| TLX3 | 0 | 0 | |||
| TMEM127 | 0 | 0 | |||
| TMEM132D | 0 | 0 | |||
| TMEM67 | 0 | 0 | |||
| TMPRSS15 | 0 | 0 | |||
| TMPRSS2 | 0 | 0 | |||
| TNF | 0 | 0 | |||
| TNFAIP3 | 0 | 0 | |||
| TNFRSF11A | 0 | 0 | |||
| TNFRSF14 | 0 | 0 | |||
| TNFRSF17 | 0 | 0 | |||
| TNFRSF19 | 0 | 0 | |||
| TNFRSF8 | 0 | 0 | |||
| TNFSF11 | 0 | 0 | |||
| TNFSF13B | 0 | 0 | |||
| TNK2 | 0 | 0 | |||
| TNKS | 0 | 0 | |||
| TNKS2 | 0 | 0 | |||
| TNN | 0 | 0 | |||
| TNPO1 | 0 | 0 | |||
| TNR | 0 | 0 | |||
| TNRC18 | 0 | 0 | |||
| TOE1 | 0 | 0 | |||
| TOP1 | 结直肠癌,卵巢癌 | 卡铂,环磷酰胺,伊立替康,拓扑替康, | 2 | 3 | |
| TOP2A | 乳腺癌 | 多柔比星, | 1 | 1 | |
| TOP2B | 0 | 0 | |||
| TOP3A | 0 | 0 | |||
| TOPBP1 | 0 | 0 | |||
| TP53 | 急性髓细胞白血病,肾上腺皮质癌,乳腺癌,癌症,宫颈癌,慢性淋巴细胞白血病,CLL/SLL,结直肠癌,食管癌,食管鳞状细胞癌,胃腺癌,头颈鳞状细胞癌,白血病,李夫琅梅尼综合征,肺腺癌癌细胞瘤,肺癌,非小细胞肺癌,淋巴瘤,骨髓增生异常综合征,骨髓瘤,神经母细胞瘤,少突胶质瘤,口腔鳞状细胞癌,卵巢癌,前体B淋巴细胞淋巴瘤/白血病,唾液腺粘液腺癌,肉瘤,皮肤鳞状细胞癌,胃癌胃癌,华登斯特巨球蛋白血症 | Adjuvant Chemotherapy,阿仑单抗,AMGMDS3,硼替佐米,卡培他滨,西妥昔单抗,Chemotherapy,EAP Protocol,Nutlin-3a,帕唑帕尼,培唑帕尼,RG7112,司美替尼,维莫非尼,维奈妥拉/维耐托克, | 卡铂,顺铂,多西他赛,多柔比星,依托泊苷,丝裂霉素,奥沙利铂,他莫昔芬, | 53 | 138 |
| TP53BP1 | 0 | 0 | |||
| TP63 | 0 | 0 | |||
| TP73 | 0 | 0 | |||
| TPH1 | 0 | 0 | |||
| TPM3 | 0 | 0 | |||
| TPMT | 0 | 0 | |||
| TPR | 0 | 0 | |||
| TPT1 | 黑色素瘤 | Sertraline (INN), | 1 | 1 | |
| TPX2 | 0 | 0 | |||
| TRA2A | 0 | 0 | |||
| TRAF2 | 0 | 0 | |||
| TRAF5 | 0 | 0 | |||
| TRAF7 | 0 | 0 | |||
| TRAP1 | 0 | 0 | |||
| TRERF1 | 0 | 0 | |||
| TRIM24 | 0 | 0 | |||
| TRIM58 | 0 | 0 | |||
| TRIO | 0 | 0 | |||
| TRPC5 | 0 | 0 | |||
| TRPS1 | 0 | 0 | |||
| TRRAP | 0 | 0 | |||
| TSC1 | 膀胱癌,浸润性膀胱移行细胞癌,非小细胞肺癌,肾细胞癌,结节性硬化症 | 依维莫司,MTOR Inhibitors,西罗莫司, | 3 | 8 | |
| TSC2 | 肾细胞癌,甲状腺癌,结节性硬化 | 依维莫司,MTOR Inhibitors, | 2 | 3 | |
| TSHR | 0 | 0 | |||
| TSHZ2 | 0 | 0 | |||
| TSHZ3 | 0 | 0 | |||
| TSN | 0 | 0 | |||
| TSPYL1 | 前列腺癌 | 1 | 1 | ||
| TTF1 | 肺腺癌 | 1 | 1 | ||
| TTL | 0 | 0 | |||
| TUBA1A | 0 | 0 | |||
| TUBA3C | 0 | 0 | |||
| TUBB | 0 | 0 | |||
| TUBB3 | 乳腺癌,癌症 | Taxane, | 紫杉醇, | 1 | 2 |
| TUBB4A | 0 | 0 | |||
| TUBB4B | 0 | 0 | |||
| TUBB6 | 0 | 0 | |||
| TUBD1 | 0 | 0 | |||
| TUBE1 | 0 | 0 | |||
| TUBG1 | 0 | 0 | |||
| TUSC3 | 0 | 0 | |||
| TWIST1 | 0 | 0 | |||
| TXNIP | 0 | 0 | |||
| TXNRD1 | 0 | 0 | |||
| TYK2 | 0 | 0 | |||
| TYMP | 0 | 0 | |||
| TYMS | 癌症,结直肠癌,胃腺癌,肺腺癌,非小细胞肺癌,前列腺癌 | 氟尿嘧啶,伊立替康,甲氨蝶呤,培美曲塞,雷替曲塞, | 5 | 8 | |
| TYR | 0 | 0 | |||
| TYRO3 | 0 | 0 | |||
| TYRP1 | 0 | 0 |
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