菜单 基因医生

在人类中，ZIM2和PEG3被视为两个不同的基因，尽管它们共享多个5'外显子和一个共同的启动子，并且这两个基因都是父系表达的（PMID:15203203）选择性剪接事件将它们共享的5'外显子与Zim2特有的其余4个外显子或PEG3特有的其余2个外显子连接起来。相比之下，在其他哺乳动物中，ZIM2不经历印记，在小鼠、奶牛和可能的其他哺乳动物中，ZIM2和PEG3基因也不共享外显子人peg3蛋白属于kruppel c2h2型锌指蛋白家族。peg3可能在细胞增殖和p53介导的凋亡中起作用。peg3在胶质瘤和卵巢细胞中也显示了肿瘤抑制活性和肿瘤发生。这个PEG3基因的选择性剪接导致编码不同亚型的多个转录变体[由RefSeq提供，2009年9月]
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]