菜单 基因医生

该基因编码的蛋白属于BCL2蛋白家族BCL2家族成员形成异二聚体或同二聚体，并作为抗或促凋亡调节因子参与多种细胞活动该基因的过度表达已被证明可诱导细胞凋亡。三个选择性剪接的转录变异体编码两个不同的亚型已经报道了这个基因。[由RefSeq提供，2009年5月]
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]