| 基因名 | 疾病 | 靶向药 | 化疗药 | 基因突变 | 临床解释 |
|---|---|---|---|---|---|
| BRAF | 未分化甲状腺癌,乳腺癌,癌症,胆管癌,透明细胞肉瘤,结肠癌,结直肠癌,神经节胶质瘤,胃肠神经内分泌肿瘤,胃肠道间质瘤,多形胶质母细胞瘤,毛细胞白血病,组织细胞瘤,朗格汉斯细胞组织细胞病,LAR咽鳞状细胞癌,肺腺癌,非小细胞肺癌,恶性结膜黑色素瘤,恶性胶质瘤,恶性周围神经鞘肿瘤,黑色素瘤,多发性骨髓瘤,骨髓瘤,卵巢癌,卵巢囊腺癌,卵巢浆液性癌,胰腺癌,乳头状甲状腺癌,PEDI心房低级别胶质瘤（PLGG）,毛细胞星形细胞瘤,多形性黄原性星形细胞瘤,肉瘤,皮肤黑色素瘤,梭形细胞肉瘤,甲状腺癌 | 阿培利司,Refametinib,贝伐单抗,Dactolisib,比美替尼、贝美替尼,BMS-754807,卡培他滨,西妥昔单抗,CI-1040,考比替尼,达拉非尼,达沙替尼,康奈非尼,厄洛替尼,依维莫司,Fluorouracil,GDC-0879,Pictilisib,吉非替尼,GSK 1120212,LY3009120,MEK Inhibitor,Nutlin-3,帕尼单抗,PD0325901,PD 0325901,帕妥珠单抗,Pictilisib,PLX4720,RDEA119,瑞戈非尼,RO4987655,司美替尼,索拉非尼,TAK-733,西罗莫司,曲美替尼,U0126,维莫非尼, | 伊立替康,奥沙利铂, | 59 | 303 |
| BRCA1 | 乳腺癌,癌症,上皮性卵巢癌,Her2受体阴性乳腺癌,恶性间皮瘤,卵巢癌,卵巢浆膜癌,胰腺癌,前列腺癌,三受体阴性乳腺癌 | 西地尼布,CX-3543,CX-5461,奥拉帕利,PLATINUM,卢卡帕尼,他拉唑帕尼,Taxane,维利帕尼, | 卡铂,顺铂,吉西他滨,长春瑞滨, | 20 | 46 |
| BRCA2 | 乳腺癌,癌症,上皮性卵巢癌,HER2受体阴性乳腺癌,卵巢癌,卵巢浆液性癌,胰腺癌,前列腺癌,三受体阴性乳腺癌 | 西地尼布,CX-3543,CX-5461,Iniparib,丝裂霉素C,奥拉帕利,PLATINUM,卢卡帕尼,他拉唑帕尼,维利帕尼, | 卡铂,顺铂,吉西他滨, | 12 | 36 |
| BAP1 | 透明细胞肾细胞癌,恶性间皮瘤,肾癌,肾细胞癌,葡萄膜黑色素瘤 | 依维莫司,Apitolisib,LBH-589,MC1568,Mocetinostat,奥拉帕利,舒尼替尼,曲古抑菌素 A,伏立诺他, | 丙戊酸钠, | 4 | 9 |
| BCL2 | 弥漫性大B细胞淋巴瘤 | 3 | 4 | ||
| BTK | 慢性淋巴细胞白血病 | 伊布替尼, | 3 | 4 | |
| BRD4 | 透明细胞肾细胞癌,坚果中线癌 | 比拉瑞塞,JQ1, | 2 | 4 | |
| BIRC5 | Her2受体阳性乳腺癌,非小细胞肺癌 | PLATINUM,Taxane,曲妥珠单抗, | 2 | 2 | |
| B2M | 结直肠癌,皮肤黑色素瘤 | 纳武单抗（纳武利尤单抗）,派姆单抗（帕博利珠单抗）, | 2 | 2 | |
| BCL2L11 | 慢性髓系白血病,非小细胞肺癌 | EGFR Inhibitor,伊马替尼, | 1 | 2 | |
| BIRC3 | 慢性淋巴细胞白血病 | 1 | 1 | ||
| BARD1 | 结直肠癌 | 奥拉帕利, | 1 | 1 | |
| B4GALT1 | 肾细胞癌 | 1 | 1 | ||
| BCOR | 胃癌 | 1 | 1 | ||
| BIRC7 | 结肠癌 | 顺铂, | 1 | 1 | |
| BCL2L1 | 0 | 0 | |||
| BCR | 0 | 0 | |||
| BLM | 0 | 0 | |||
| BTG1 | 0 | 0 | |||
| BCL6 | 0 | 0 | |||
| BMPR1A | 0 | 0 | |||
| BRIP1 | 0 | 0 | |||
| BCL2L2 | 0 | 0 | |||
| BCORL1 | 0 | 0 | |||
| BACH1 | 0 | 0 | |||
| BAD | 0 | 0 | |||
| BAX | 0 | 0 | |||
| BBC3 | 0 | 0 | |||
| BCL10 | 0 | 0 | |||
| BCL2A1 | 0 | 0 | |||
| BRD7 | 0 | 0 | |||
| BRINP3 | 0 | 0 | |||
| BTG2 | 0 | 0 | |||
| BUB1 | 0 | 0 | |||
| BUB1B | 0 | 0 | |||
| BUB3 | 0 | 0 | |||
| B4GALT3 | 0 | 0 | |||
| BABAM1 | 0 | 0 | |||
| BABAM2 | 0 | 0 | |||
| BAK1 | 0 | 0 | |||
| BAZ2B | 0 | 0 | |||
| BBS9 | 0 | 0 | |||
| BCAS1 | 0 | 0 | |||
| BCAS3 | 0 | 0 | |||
| BCL11A | 0 | 0 | |||
| BCL11B | 0 | 0 | |||
| BCL2L14 | 0 | 0 | |||
| BCL3 | 0 | 0 | |||
| BCL9 | 0 | 0 | |||
| BCLAF1 | 0 | 0 | |||
| BICC1 | 0 | 0 | |||
| BIRC2 | 0 | 0 | |||
| BLCAP | 0 | 0 | |||
| BLK | 0 | 0 | |||
| BMPR2 | 0 | 0 | |||
| BMX | 0 | 0 | |||
| BNC2 | 0 | 0 | |||
| BORCS8-MEF2B | 0 | 0 | |||
| BPTF | 0 | 0 | |||
| BRCC3 | 0 | 0 | |||
| BRD2 | 0 | 0 | |||
| BRD3 | 0 | 0 | |||
| BRF1 | 0 | 0 | |||
| BRMS1L | 0 | 0 | |||
| BRS3 | 0 | 0 | |||
| BRSK1 | 0 | 0 | |||
| BRWD1 | 0 | 0 | |||
| BTF3 | 0 | 0 | |||
| BTLA | 0 | 0 |
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