菜单 基因医生

这个基因编码的蛋白质属于parp家族。这些酶通过聚adp核糖化修饰核蛋白,这是dna修复、细胞凋亡调节和维持基因组稳定性所必需的。该基因编码聚腺苷二磷酸核糖转移酶3,在整个细胞周期中优先定位于子中心粒。另外,还发现了编码不同亚型的剪接转录变体。[由RefSeq提供,2008年7月]
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

基因名:PARP3
别名:IRT1,ARTD3,ADPRT3,ADPRTL2,ADPRTL3,PADPRT-3
基因ID:10039
Chromosome:
(GRCh37)
3 Start: 51976297 End: 51982883 Strand: 
信号通路: 细胞增殖  凋亡抑制  能量代谢 
PARP3 基因突变与药物