菜单 基因医生

组蛋白在转录调控、细胞周期进展和发育事件中起着关键作用。组蛋白乙酰化/去乙酰化改变染色体结构并影响转录因子对dna的获取。该基因编码的蛋白质与组蛋白脱乙酰酶家族成员具有序列同源性。该基因与非洲爪蟾和小鼠二尖瓣基因同源。mitr蛋白缺乏组蛋白脱乙酰酶催化结构域。它通过招募包括ctbp和hdac的多组分共加压复合物来抑制mef2活性。这种编码蛋白可能在造血中起作用。已经描述了该基因的多个选择性剪接转录本，但其中一些转录本的全长性质尚未确定。[由RefSeq提供，2008年7月]
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]