菜单 基因医生

组蛋白是构成真核生物染色体纤维核小体结构的基本核蛋白四个核心组蛋白(H2A、H2B、H3和H4)中的每一个分子形成一个八聚体,其中大约146 bp的DNA被包裹在被称为核小体的重复单元中。连接组蛋白H1在核小体之间与连接DNA相互作用,在染色质压缩成高阶结构中发挥作用该基因无内含子,编码一个复制依赖性组蛋白,是组蛋白h3家族的成员。这个基因的转录本没有polya尾,而是包含一个回文终止元素。该基因存在于6p22-p21.3染色体上的小组蛋白基因簇中。[由RefSeq提供,2015年8月]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

基因名:H3C10
别名:H3/k,H3C1,H3C2,H3C3,H3C4,H3C6,H3C7,H3C8,H3FK,H3C11,H3C12,H3F1K,HIST1H3H
基因ID:8357
Chromosome:
(GRCh37)
6 Start: 27777842 End: 27778314 Strand: 
信号通路:  
H3C10 基因突变与药物