菜单 基因医生

钙蛋白酶是一个普遍存在的、保存良好的钙依赖性半胱氨酸蛋白酶家族calpain蛋白是由不变的小亚基和可变的大亚基组成的异二聚体大亚单位具有半胱氨酸蛋白酶结构域，并且两个亚单位都具有钙结合结构域钙蛋白酶被牵连在神经退行性过程中，因为它们的激活可以由钙内流和氧化应激触发。这个基因编码的蛋白质的功能尚不清楚。在老鼠身上发现了一个正射影像，但它似乎与其他家庭成员不同。小鼠原肠被认为是钙独立的蛋白酶活性。[由RefSeq提供，2008年7月]
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]