菜单 基因医生

该基因编码一种转录因子,属于碱性区亮氨酸拉链因子家族(cnc-bzip)的帽领型。编码蛋白包含广泛的复合物、tramrack、bric-a-brac/poxvirus和锌指(btb/poz)结构域,这是cnc-bzip家族成员的非典型结构域。这些btb/poz结构域促进了蛋白质-蛋白质相互作用和同源和/或杂寡聚体的形成。当这种编码的蛋白质与mafk形成异二聚体时,它作为maf识别元件(mare)的阻遏物发挥作用,并且转录被抑制。已鉴定出该基因的多个选择性剪接转录变体。[由RefSeq提供,2009年5月]
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]

基因名:BACH1
别名:BACH-1,BTBD24
基因ID:571
Chromosome:
(GRCh37)
21 Start: 30671151 End: 30734257 Strand: 
信号通路:  
BACH1 基因突变与药物