| 基因名 | 疾病 | 靶向药 | 化疗药 | 基因突变 | 临床解释 |
|---|---|---|---|---|---|
| SMO | 基底细胞癌,脑髓母细胞瘤,癌,非小细胞肺癌,髓母细胞瘤,脑膜瘤,嗅槽型脑膜瘤 | 吉非替尼,LDE225,PSI,Saridegib,维莫德吉, | 三氧化二砷, | 18 | 35 |
| STK11 | 乳腺癌,肺腺癌,非小细胞肺癌,胰腺癌,Peutz-Jeghers综合征,前列腺癌 | CI-1040,依维莫司,依西美坦,派姆单抗（帕博利珠单抗）,纳武单抗（纳武利尤单抗）,阿特朱单抗，阿替利珠单抗,西罗莫司,SB202190,司美替尼,Sirolimus, | 多西他赛, | 7 | 17 |
| SMAD4 | 结直肠癌,头颈鳞状细胞癌,青少年息肉综合征,非小细胞肺癌,胰腺腺癌,胰腺癌,胰管腺癌,前列腺癌 | 西妥昔单抗,帕尼单抗, | 氟尿嘧啶,吉西他滨,赖氨酸, | 7 | 15 |
| SF3B1 | 乳腺癌,慢性淋巴细胞白血病,骨髓增生异常综合征 | Spliceostatin A, | 3 | 9 | |
| SMARCA4 | 肺腺癌,非小细胞肺癌,卵巢小细胞癌,卵巢小细胞癌高钙型,实体瘤 | 玻玛西林,玻玛西尼,哌柏西利,帕博西尼,帕博西林,瑞博西尼,他泽司他,Tozasertib(MK-0457,VX-680), | 顺铂,长春瑞滨, | 4 | 8 |
| SSX1 | 周围神经鞘恶性肿瘤,滑膜肉瘤 | 1 | 7 | ||
| STAG2 | 急性髓性白血病,膀胱癌,膀胱尿路上皮乳头状癌,骨尤因肉瘤,黑色素瘤 | 维莫非尼, | 2 | 5 | |
| SMARCB1 | 横纹肌样癌,实体瘤,滑膜肉瘤 | 他泽司他,帕比司他,他泽司他, | 2 | 4 | |
| SSX2 | 滑膜肉瘤 | 1 | 4 | ||
| SGK1 | 乳腺癌 | 阿培利司,SGK1-Inh, | 1 | 3 | |
| SETBP1 | 慢性粒细胞白血病,少年粒细胞白血病 | 3 | 3 | ||
| SLFN11 | 结直肠癌,尤因肉瘤,小细胞肺癌 | 尼拉帕尼,SN-38,他拉唑帕尼,替莫唑胺, | 1 | 3 | |
| SLCO1B1 | 癌症 | 甲氨蝶呤, | 2 | 2 | |
| SIRT1 | 胰腺癌 | 烟酰胺, | 1 | 2 | |
| STMN1 | 子宫内膜癌 | 紫杉醇, | 1 | 1 | |
| SCN8A | 肺腺癌 | 派姆单抗（帕博利珠单抗）, | 1 | 1 | |
| SDHB | 副神经节瘤 | 1 | 1 | ||
| SRSF2 | 急性髓性白血病 | 1 | 1 | ||
| SOX10 | 黑色素瘤 | 维莫非尼, | 1 | 1 | |
| SSX4 | 滑膜肉瘤 | 1 | 1 | ||
| STAT3 | T细胞大颗粒淋巴细胞白血病 | 1 | 1 | ||
| SYK | 卵巢癌 | 紫杉醇, | 1 | 1 | |
| SPHK1 | 宫颈癌 | 1 | 1 | ||
| SH2B3 | 结直肠癌 | 1 | 1 | ||
| SPRY2 | 胃腺癌 | 1 | 1 | ||
| STAG3 | 黑色素瘤 | 维莫非尼, | 1 | 1 | |
| SUFU | 髓母细胞瘤 | 索尼德吉, | 1 | 1 | |
| SMARCD1 | 0 | 0 | |||
| SRC | 0 | 0 | |||
| SNCAIP | 0 | 0 | |||
| SLC19A1 | 0 | 0 | |||
| SOCS1 | 0 | 0 | |||
| SPINK1 | 0 | 0 | |||
| SMAD2 | 0 | 0 | |||
| SMAD3 | 0 | 0 | |||
| STAT4 | 0 | 0 | |||
| SLIT2 | 0 | 0 | |||
| SPTA1 | 0 | 0 | |||
| SOD2 | 0 | 0 | |||
| SLC22A16 | 0 | 0 | |||
| SDHA | 0 | 0 | |||
| SDHC | 0 | 0 | |||
| SDHD | 0 | 0 | |||
| SETD2 | 0 | 0 | |||
| SLCO1B3 | 0 | 0 | |||
| SDHAF2 | 0 | 0 | |||
| SOX2 | 0 | 0 | |||
| SOX9 | 0 | 0 | |||
| SNAI1 | 0 | 0 | |||
| SPEN | 0 | 0 | |||
| SPOP | 0 | 0 | |||
| SBDS | 0 | 0 | |||
| SDC4 | 0 | 0 | |||
| SLC28A3 | 0 | 0 | |||
| SLC34A2 | 0 | 0 | |||
| SLX4 | 0 | 0 | |||
| SMARCAL1 | 0 | 0 | |||
| SMARCE1 | 0 | 0 | |||
| SOS1 | 0 | 0 | |||
| SOX17 | 0 | 0 | |||
| STAT5A | 0 | 0 | |||
| STAT5B | 0 | 0 | |||
| STK40 | 0 | 0 | |||
| SULT1A1 | 0 | 0 | |||
| SUZ12 | 0 | 0 | |||
| SVEP1 | 0 | 0 | |||
| SERPINB4 | 0 | 0 | |||
| SH2D1A | 0 | 0 | |||
| SHQ1 | 0 | 0 | |||
| SLC22A2 | 0 | 0 | |||
| SERPINB3 | 0 | 0 | |||
| SKP2 | 0 | 0 | |||
| SALL1 | 0 | 0 | |||
| SAMD9 | 0 | 0 | |||
| SASH1 | 0 | 0 | |||
| SATB2 | 0 | 0 | |||
| SBNO2 | 0 | 0 | |||
| SCG5 | 0 | 0 | |||
| SCUBE2 | 0 | 0 | |||
| SDCCAG8 | 0 | 0 | |||
| SEC31A | 0 | 0 | |||
| SEL1L3 | 0 | 0 | |||
| SEMA3A | 0 | 0 | |||
| SEMA3C | 0 | 0 | |||
| SEMA3E | 0 | 0 | |||
| SEMA6A | 0 | 0 | |||
| Sept14 | 0 | 0 | |||
| Sept9 | 0 | 0 | |||
| SERP2 | 0 | 0 | |||
| SERPINA7 | 0 | 0 | |||
| SESN1 | 0 | 0 | |||
| SESN2 | 0 | 0 | |||
| SESN3 | 0 | 0 | |||
| SETDB1 | 0 | 0 | |||
| SETMAR | 0 | 0 | |||
| SF1 | 0 | 0 | |||
| SF3A1 | 0 | 0 | |||
| SF3A3 | 0 | 0 | |||
| SFPQ | 0 | 0 | |||
| SFXN4 | 0 | 0 | |||
| SGCZ | 0 | 0 | |||
| SH2D2A | 0 | 0 | |||
| SH3PXD2A | 0 | 0 | |||
| SHBG | 0 | 0 | |||
| SHH | 0 | 0 | |||
| SHMT1 | 0 | 0 | |||
| SHOC2 | 0 | 0 | |||
| SHPRH | 0 | 0 | |||
| SHROOM3 | 0 | 0 | |||
| SI | 0 | 0 | |||
| SIK1 | 0 | 0 | |||
| SIMC1 | 0 | 0 | |||
| SIN3A | 0 | 0 | |||
| SIPA1 | 0 | 0 | |||
| SIPA1L2 | 0 | 0 | |||
| SIX1 | 0 | 0 | |||
| SLAMF7 | 0 | 0 | |||
| SLC10A2 | 0 | 0 | |||
| SLC14A2 | 0 | 0 | |||
| SLC16A1 | 0 | 0 | |||
| SLC16A7 | 0 | 0 | |||
| SLC1A2 | 0 | 0 | |||
| SLC22A18 | 0 | 0 | |||
| SLC22A3 | 0 | 0 | |||
| SLC22A4 | 0 | 0 | |||
| SLC30A5 | 0 | 0 | |||
| SLC31A1 | 0 | 0 | |||
| SLC3A2 | 0 | 0 | |||
| SLC45A2 | 0 | 0 | |||
| SLC45A3 | 0 | 0 | |||
| SLC4A1 | 0 | 0 | |||
| SLC6A3 | 0 | 0 | |||
| SLC7A8 | 0 | 0 | |||
| SLC8A1 | 0 | 0 | |||
| SLIT1 | 0 | 0 | |||
| SLIT3 | 0 | 0 | |||
| SLITRK1 | 0 | 0 | |||
| SLITRK2 | 0 | 0 | |||
| SLITRK3 | 0 | 0 | |||
| SLX1A | 0 | 0 | |||
| SMAD7 | 0 | 0 | |||
| SMARCA1 | 0 | 0 | |||
| SMARCA2 | 0 | 0 | |||
| SMARCC1 | 0 | 0 | |||
| SMARCC2 | 0 | 0 | |||
| SMC1A | 0 | 0 | |||
| SMC1B | 0 | 0 | |||
| SMC3 | 0 | 0 | |||
| SMCHD1 | 0 | 0 | |||
| SMURF2 | 0 | 0 | |||
| SMYD3 | 0 | 0 | |||
| SNAI2 | 0 | 0 | |||
| SNTG1 | 0 | 0 | |||
| SNX29 | 0 | 0 | |||
| SNX6 | 0 | 0 | |||
| SORBS2 | 0 | 0 | |||
| SOX1 | 0 | 0 | |||
| SOX14 | 0 | 0 | |||
| SOX21 | 0 | 0 | |||
| SOX4 | 0 | 0 | |||
| SPC24 | 0 | 0 | |||
| SPG7 | 0 | 0 | |||
| SPHKAP | 0 | 0 | |||
| SPOPL | 0 | 0 | |||
| SPRED1 | 0 | 0 | |||
| SPRR3 | 0 | 0 | |||
| SPRY4 | 0 | 0 | |||
| SPSB4 | 0 | 0 | |||
| SRCAP | 0 | 0 | |||
| SRD5A2 | 0 | 0 | |||
| SRGAP1 | 0 | 0 | |||
| SRGAP3 | 0 | 0 | |||
| SRMS | 0 | 0 | |||
| SRP19 | 0 | 0 | |||
| SRSF7 | 0 | 0 | |||
| SRY | 0 | 0 | |||
| SS18 | 0 | 0 | |||
| SSTR2 | 0 | 0 | |||
| ST3GAL3 | 0 | 0 | |||
| ST6GAL2 | 0 | 0 | |||
| ST6GALNAC3 | 0 | 0 | |||
| STAG1 | 0 | 0 | |||
| STARD4 | 0 | 0 | |||
| STAT1 | 0 | 0 | |||
| STAT2 | 0 | 0 | |||
| STAT6 | 0 | 0 | |||
| STK19 | 0 | 0 | |||
| STK24 | 0 | 0 | |||
| STK4 | 0 | 0 | |||
| STRBP | 0 | 0 | |||
| STT3A | 0 | 0 | |||
| SUB1 | 0 | 0 | |||
| SUCLG1 | 0 | 0 | |||
| SUCLG2 | 0 | 0 | |||
| SUGCT | 0 | 0 | |||
| SYNCRIP | 0 | 0 | |||
| SYNE1 | 0 | 0 |
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