| 基因名 | 疾病 | 靶向药 | 化疗药 | 基因突变 | 临床解释 |
|---|---|---|---|---|---|
| KRAS | 急性白血病,癌症,慢性骨髓单核细胞白血病,透明细胞肉瘤,结肠癌,结直肠癌,子宫内膜癌,上皮性卵巢癌,毛细胞白血病,头颈部鳞状细胞癌,肝细胞癌,肺腺癌,肺癌,非小细胞肺癌肿瘤,肺鳞状细胞癌,淋巴瘤,黑色素瘤,多发性骨髓瘤,骨髓瘤,卵巢癌,胰腺腺癌,胰腺癌,胰腺导管癌,毛细胞星形细胞瘤,腹膜假黏液瘤,罗莎多夫曼病,皮肤黑色素瘤,皮肤鳞状细胞癌,甲状腺癌,甲状腺癌D癌,外分泌胰腺肿瘤 | 玻玛西林,玻玛西尼,Adoptive T-cell Transfer,阿法替尼,司美替尼,ARS-1620,ARS-853,阿特朱单抗，阿替利珠单抗,AZD5438,AZD8186,Refametinib,贝伐单抗,Dactolisib,比美替尼、贝美替尼,BMS-754807,西妥昔单抗,Chemotherapy,考比替尼,克唑替尼,达拉非尼,达沙替尼,Decitabine,EGFR Inhibitor,康奈非尼,厄洛替尼,Fluorouracil,G-573,GDC-0623,吉非替尼,GO-203-2C,IMO,伊沙佐米,Leucovorin,玻玛西林,玻玛西尼,MEK Inhibitor,马法兰，米尔法兰,MK-2206,纳武单抗（纳武利尤单抗）,Oxaliplatin (JAN/USAN/INN),哌柏西利,帕博西尼,帕博西林,帕尼单抗,PD0325901,哌柏西利,帕博西尼,帕博西林,派姆单抗（帕博利珠单抗）,PI103,PI3K Inhibitor,R1507,RAF265,Refametinib,瑞戈非尼,Ridaforolimus,RO4987655,SCH772984,司美替尼,Small Molecule Inhibitor,索拉非尼,舒尼替尼,西罗莫司,曲美替尼,维莫非尼, | 卡铂,顺铂,多西他赛,反法尼基硫代水杨酸,FOLFOX4方案,吉西他滨,伊立替康,奥沙利铂,紫杉醇,培美曲塞,沙利雷塞, | 35 | 397 |
| KIT | 肢端扁桃体黑色素瘤,急性髓系白血病,急性早幼粒细胞白血病,癌症,慢性白血病,慢性髓系白血病,结肠印戒腺癌,子宫内膜癌,胃肠道间质瘤,胃肠道系统癌,肺腺癌,肺癌,非小细胞肺癌,恶性肛门梅尔异常瘤,黑色素瘤,粘膜黑色素瘤,鼻腔未分化癌,实体瘤,全身肥大细胞增多症,胸腺癌,胸腺鳞状细胞癌 | 达沙替尼,博舒替尼,克唑替尼,达沙替尼,Gleevec,伊马替尼,Imatinib Mesylate,米哚妥林,坦度替尼,尼洛替尼,PD-180970,Pictilisib,帕纳替尼/普纳替尼/波纳替尼,瑞戈非尼,司美替尼,索拉非尼,舒尼替尼,舒尼替尼, | 87 | 329 | |
| KDR | 血管肉瘤,乳腺血管肉瘤,结直肠癌 | 帕唑帕尼,培唑帕尼,瑞戈非尼,索拉非尼,舒尼替尼, | 5 | 5 | |
| KMT2D | 滤泡性淋巴瘤,歌舞伎综合征 | AR-42, | 2 | 2 | |
| KLLN | 乳腺癌,肾细胞癌 | 1 | 2 | ||
| KMT2C | 乳腺癌 | Anastrozole,依西美坦,来曲唑片, | 2 | 2 | |
| KIAA1524 | 胰腺导管腺癌 | 吉西他滨, | 2 | 2 | |
| KRT18 | 前列腺癌 | 1 | 1 | ||
| KMT2A | 急性髓性白血病 | 1 | 1 | ||
| KDM6A | 急性淋巴细胞白血病 | 1 | 1 | ||
| KDM5C | 肾细胞癌 | 依维莫司,舒尼替尼, | 1 | 1 | |
| KIF23 | 肝细胞癌 | 1 | 1 | ||
| KAT6A | 0 | 0 | |||
| KDM5A | 0 | 0 | |||
| KLHL6 | 0 | 0 | |||
| KEL | 0 | 0 | |||
| KEAP1 | 0 | 0 | |||
| KIF5B | 0 | 0 | |||
| KLF4 | 0 | 0 | |||
| KMT2B | 0 | 0 | |||
| KALRN | 0 | 0 | |||
| KAT6B | 0 | 0 | |||
| KCNA4 | 0 | 0 | |||
| KCND2 | 0 | 0 | |||
| KCNJ2 | 0 | 0 | |||
| KCNJ3 | 0 | 0 | |||
| KCNJ5 | 0 | 0 | |||
| KCNQ2 | 0 | 0 | |||
| KCNT2 | 0 | 0 | |||
| KDM2B | 0 | 0 | |||
| KDM3B | 0 | 0 | |||
| KDM4C | 0 | 0 | |||
| KDM5D | 0 | 0 | |||
| KIAA1210 | 0 | 0 | |||
| KIAA1217 | 0 | 0 | |||
| KIAA1549 | 0 | 0 | |||
| KIF1B | 0 | 0 | |||
| KIF2B | 0 | 0 | |||
| KIR3DX1 | 0 | 0 | |||
| KITLG | 0 | 0 | |||
| KLB | 0 | 0 | |||
| KLC1 | 0 | 0 | |||
| KLF5 | 0 | 0 | |||
| KLF6 | 0 | 0 | |||
| KLHL1 | 0 | 0 | |||
| KLK1 | 0 | 0 | |||
| KMT2E | 0 | 0 | |||
| KMT5A | 0 | 0 | |||
| KNSTRN | 0 | 0 | |||
| KPNA4 | 0 | 0 | |||
| KPNB1 | 0 | 0 | |||
| KRTAP5-5 | 0 | 0 |
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